Selected Residue / Sequence Deleted Residue / Sequence 10 20 30 40 50 60 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 MSNTVNFNRYGD-QPGDLYDAQTDSC-QTSESQ-----------FP---VLSSLKPYFCQ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ---------------------MYE-----DDI---------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ---------------------MLD---------------------------SATKC---- Pinctada-fucata_pfu26-120078t1_NONE ---------------------MESTC-NSEENSRIDV-------LP---GMDVGP----- Pinctada-fucata_pfu930-101250t1_NONE ------------------MIFQGP----NPD-------------LP-------MA----- Pinctada-fucata_pfu5110-102705t1_NONE MANATGYPAYPDSRLESTYTANAERC-LESEGH-----------Y----TLPSLKPYYCE Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ---------------------MSKRC-ASDRDDK-------------------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ---------------------MNR------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -----------------------------------------------------MA----- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------MITMNE----LVDLR--------------------M------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------MLSMQE----LMDMR--------------------M------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -------MRY----DVQELLFHQS----AED--------------PFARFANGMA----- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------------------MMAHY-EVSQHH---------------QFAASMG----- Saccoglossus-kowalevskii_Sakowv30012255_NONE ---------------------MYE----SDDI---------------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ---------------------MTT---------------------------VDMK----- Ptychodera-flava_PF12118-t1_NONE ---------------------MLA------------------------------------ Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE --------------------MMYE----SEDI---------------------------- Ptychodera-flava_PF18670-t1_NONE ------MTAYRC-APYIGTPSMST---------------------------IAMK----- Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE -------------------MELSEKA----------------SAFSIESLMSGSS----- Acanthaster-planci_oki169-35_NONE ---------------------MED--------------------------HESGS----- Acanthaster-planci_oki20-22_NONE ---------------------MLR--------------GEFGSKLP--PVGQGERYTVSH Acanthaster-planci_oki15-190_NONE ---------------------MSA---------------------------DTMR----- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte --------------------MMGEELQHTTDQGNEHV-----------AATNPTKF---- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara -----------------------------------------------------MA----- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------MPAMSA---------------------------DALR----- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like --------------------MMYE----SEDV---------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ---------------------MQQSC-APGEPG-----------F--------------H Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -----------------------------------------------------MK----- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform --------------------MSSA---------------------------ETMK----- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like --------------------MMYE----SEDV---------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ---------------------MQQSC-APGEAG-----------F--------------Q Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -----------------------------------------------------MK----- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo --------------------MSSA---------------------------ETMK----- Oikopleura-dioica_GSOIDT00014261001_NONE ---------------------MDN------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ---------------------MNT------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE -----------------------------MDQG--------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE ------------------------------------------------MIQESMK----- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ---------------MERNSGVWR----TEDI---------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ----------------------MA---------------------------TTGK----- Ciona-intestinalis_ENSCINT00000017704.3_NONE -------------------MCLTD----SEDQTRSSSPLEHHFNLPTPMIQDSMK----- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ---------------MEDSSCLRK----TGDM---------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ---------------------MSQ-------------------QYP-------------- Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------------MQLGEPL-LAAAGG----------------ALPGAPFYPLE Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -------------------MQL-EHC-LSPSI------------------MLSKKFLNVS Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ---------------------MAD----TEEGF-------------------GLP----- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ---------------------MAD---------------------------LGCK----- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -----------------------------------------------------MG----- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -------------------MGI------------------------------------VE Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------------MQLGEQL-LVSSVN-----------------LPGAHFYPLE Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc -------------------MQL-EHC-LSPSI------------------MLSKKFLNVS Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ---------------------MAD----ADEGF-------------------GLA----- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -------------------MAMSE---------------------------LGTR----- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -----------------------------------------------------MS----- 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 DYLSQDPGQ-------DVQHPLTQYSHH----------------SLDTHNQDKHFDEP-- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 -----------------------------------------------ISQRARAFPLG-- Crassostrea-gigas_EKC28765_Brachyury-protein -----------------DFQPFSVKSEIGTN----------RGTQEKSEMKSTQLNVS-- Pinctada-fucata_pfu26-120078t1_NONE ------------------SSPN----------------------KTPLSSKATAFSIA-- Pinctada-fucata_pfu930-101250t1_NONE ------------------YNP-----------------------F--LLHRPADY----- Pinctada-fucata_pfu5110-102705t1_NONE GYAYPEGQQ-------Q-----SSYTHL----------------TPENSSPEKSYEET-- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 -----------------DSEPV----------------------------KKPRFSIA-- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa -----------------------------------------------------NFSID-- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------FNP-----------------------FA-------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -----------------------------------------------QQHIAHEIYRQ-- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -----------------------------------------------QQQLAHEIYRQ-- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ------------------YHP-----------------------FLQLTQRPTDFSVS-- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------MTTS-- Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------NQPHASNRQNRMN----------VLHVSGEEPTDAGFSIN-- Saccoglossus-kowalevskii_Sakowv30012255_NONE -----------------------------------------------LSHRARAFSIN-- Saccoglossus-kowalevskii_Sakowv30011577_NONE -------------------PP--------------------------------SYNVN-- Ptychodera-flava_PF12118-t1_NONE ---------------------------------------------SDENNSDGGFTIT-- Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE -----------------------------------------------LSHRARAFSIN-- Ptychodera-flava_PF18670-t1_NONE -------------------QP--------------------------------TFNVN-- Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE -QAVRDDDDRCRSADISSCSP-------------VPKPEPPRTDSIDDGTAASRFTLS-- Acanthaster-planci_oki169-35_NONE ------------------EQP-----------------------KSQLSSRANAFSIE-- Acanthaster-planci_oki20-22_NONE HGWTKDTEQGNTNHCLAPTRPNGG--------------------GINIQSPSSQAGMQ-- Acanthaster-planci_oki15-190_NONE -------------------AP--------------------------------TYNVA-- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte --------Q-------KTTEPEESDKVYEDENLDRDDGSNGSEDTNCEKSTVEQFDTN-- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ------------------YAP-----------------------I--MPHRLSDFSVN-- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte -------------------AP--------------------------------SYNVS-- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like -----------------------------------------------LTQRARAFSIN-- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like TYGT-DTSL-------DGGGPATGPTRM------------------DAGD-DDSPGNA-- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -------------------Q------------------------------TPDQFSVS-- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -------------------Q---------------------------TAATPDQFSVS-- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -----------------------------------------------LTQRARAFSIN-- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo AYGT-DTSV-------DGGGPTSAPTRM------------------DAADVDDTAVGT-- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -------------------Q------------------------------TPDQFSVS-- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -------------------QP--------------------------TAASPDQFSVS-- Oikopleura-dioica_GSOIDT00014261001_NONE -------------------SPHEV-----------------------STIDSHEITLN-- Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE -----------------------------------------------LLPTQRS------ Oikopleura-dioica_GSOIDT00007455001_NONE --------------------------------------------------------MS-- Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE ------------------PGP-----------------------ISPLQAVMSAYNHS-- Ciona-savignyi_ENSCSAVT00000020041.1_NONE -----------------------------------------------LNLNSNS-NMR-- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE ------------------PGP-----------------------ISPLQAVMSAYNHS-- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -----------------------------------------------LDVNTNS-NLT-- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE -----------------SQVPSCVYGQSN------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin GGGR---GS-------GTGAGGGGGA--ASRG----PPRPGSPAHLDLDKAAKKF----- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -----------------SSYPHAGGSELALHD----HPIISTTDNLERSSPLKKITR--- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------STP--------------------------VDSEAKELQAE-- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -------------------KPS-------------------------------DCTVS-- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -------------------SP-------------------------EDAGKAPAYRVD-- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti --------------------PGCG------------------------------------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -----------------SARGGSGGS--AGHL----PSAAPSPQKLDLDKASKKFSGSLS Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc -----------------SSYPHSGGSELVLHD----HPIISTTDNLERSSPLKKITR--- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------HTP--------------------------LEPDAKDLPCD-- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -------------------KPS-------------------------------DGTVS-- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -------------------SPGT-----------------------ESAGKSLQYRVD-- 130 140 150 160 170 180 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------DSIN-------------------------------------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------HGLM-------------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ------------------HLLS-------------------------------------- Pinctada-fucata_pfu26-120078t1_NONE ------------------AIMGGERNQG-------------------------------- Pinctada-fucata_pfu930-101250t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu5110-102705t1_NONE ------------------EDLS-------------------------------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------NILDEVEDEE-------------------------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------AILARK------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------QIMQ-------------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------QIMQ-------------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ------------------SLLTAGSNNNNSGNTNSGNNNSNSNNNTNSNTNNTNNLVAVS Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------HILS-------------------------------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------NLLPAYRNDASNDNSNR------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------SIVS-------------------------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------HLLS-------------------------------------- Ptychodera-flava_PF12118-t1_NONE ------------------NLLSSYRDGGGGANSHAY------------------------ Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE ------------------SIVS-------------------------------------- Ptychodera-flava_PF18670-t1_NONE ------------------HLLN-------------------------------------- Acanthaster-planci_oki84-25_NONE -------------------MIA-------------------------------------- Acanthaster-planci_oki58-6_NONE ------DPVIDFSAQRAASLLRKISIRGS------------------------------- Acanthaster-planci_oki169-35_NONE ------------------ALMAGSKTRT-------------------------------- Acanthaster-planci_oki20-22_NONE -------------SGKYGQMLDDGTSRETEGQDTRN------------------------ Acanthaster-planci_oki15-190_NONE ------------------HLLS-------------------------------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ------------------KLISNADHNVGDPNN--------------------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ------------------SLLT-------------------------------------P Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------HLLN-------------------------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------NM---------------------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ------------------DTFQ-------------------------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------HLLS-------------------------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------HLLS-------------------------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ------------------NM---------------------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ------------------DSFQ-------------------------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------HLLS-------------------------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------HLLS-------------------------------------- Oikopleura-dioica_GSOIDT00014261001_NONE ------------------SLSSISKGDD-------------------------------- Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------GILS-------------------------------------- Oikopleura-dioica_GSOIDT00000279001_NONE --------------------MS-------------------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE ------------------GMLP-------------------------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------NMST-------------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------SMTS-------------------------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE ------------------GMMP-------------------------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------EMVA-------------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE -------------------MAT-------------------------------------- Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript -------------------MTS-------------------------------------- Botryllus-schlosseri_botctg005874g48703_NONE ------------------ALLV-------------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------AAAP-AMLGEPDAGE-------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ------------------GMTNQSDTDN-------------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------AKQD-------------------------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------RLLS-------------------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------HLLS-------------------------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------------DMLTGTE----------------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin CEAVSGEPAAA-SAGAPAAMLSDTDAGD-------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ------------------GMTNQSDTDN-------------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------SKPE-------------------------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------HLLN-------------------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------HLLS-------------------------------------- 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE ----------GALL---------------------------------------------- Pinctada-fucata_pfu5110-102705t1_NONE ------------------------------------------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 PT------GGGAQLSPQSNHSSSNTTTTSNTNNSSSNNNNNNSTHNNNNNHTNNNNNNNN Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ------------------------------------------------------------ Acanthaster-planci_oki169-35_NONE ------------------------------------------------------------ Acanthaster-planci_oki20-22_NONE ------------------------------------------------------------ Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara PQFFPGMFGRNACL---------------------------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE --------------------------------------------------H--------- Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ------------------------------------------------------------ Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ------------------------------------------------------------ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 250 260 270 280 290 300 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ----------------PV-----------------------------------------S Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ----------------PTPQ-------------------------AFSF----------- Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE ------------VEQYPSTS-------------------------LERS------ESAFS Pinctada-fucata_pfu930-101250t1_NONE -----QQHYLQGM-GVPNPA-------------------------GLPG----------- Pinctada-fucata_pfu5110-102705t1_NONE ----------------P------------------------------------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------DVEVDV Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -------------------L-------------------------GRPD----------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN --------------RIP------------------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN --------------RIP------------------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 NTSQKQGHHLSTTEEPPSPA-------------------------GTPPPT--------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------------TDSST-------------------------ATTTIRNDDDEETEI Saccoglossus-kowalevskii_Sakowv30012255_NONE ----------------P-PR-------------------------GFAY----------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ------------GDPDNGPS-------------------------ATPSGNSTDDEASTV Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE ----------------P-PR-------------------------GFSY----------- Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE --------------EEPENAEATI----------------ASSSGAFPE----------- Acanthaster-planci_oki169-35_NONE ------------TEAISEPR-------------------------QSAQ------NHSGY Acanthaster-planci_oki20-22_NONE --------------QHPLTV-----------NTECCTPRDAEEHITAPH------QQANL Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte --------------DYPCNKFELCEIKSNLENSQTGRQSDLFQRNGHAH-----ENAEQF Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----------------PG-A-------------------------GLPG----------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------LT-------------------------GSPH----------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ----------------PSGL-------------------------GLPY---------GM Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ------------------LT-------------------------GSPH----------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ----------------PPGL-------------------------SMPY---------GM Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ---------------------------------------------AEPY----------- Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ----------------P-TE-------------------------GTGYADLTDWTCTMI Oikopleura-dioica_GSOIDT00007455001_NONE -------------------N-------------------------SYPG----------- Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE ---------------------------------------------SRSG----------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE VLAQRQEHTFT-----E-IS-------------------------NAPH----------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE ---------------------------------------------SRPG----------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri PAAV---CNFR-----PDLN-------------------------TSGL----------- Ciona-intestinalis_ENSCINT00000034896.1_NONE DVRG---STFE-----P------------------------------------------- Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE --------------QDPCNG---------------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------PPFAAPK---------------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ---------------FPDSK-------------------------DTPG----------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ----------------P-QL-------------------------GTTS----------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti --------------PMPGSDE-----------------------GRAPG----------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin --------------AFASAAA-----------------------VAKPG----------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ---------------FPDSK-------------------------DSPG----------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ----------------S-AL-------------------------GAPS----------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 S---------------SEYTPPRDS----------------------------HGAS--- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 -------------------GFPMHP----------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE T---------------EIPPVPKIP----------------------------------- Pinctada-fucata_pfu930-101250t1_NONE ------------------SLLPKLQ----------------------------------- Pinctada-fucata_pfu5110-102705t1_NONE N---------------AGYQSPGSG----------------------------GTPS--- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 E----------DVDDVDLSSIPSKS----------------------------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ---------------------PVEK----------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------LLLPFM------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------DPFPPM------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------DPFPSM------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -----------------IVGLPPIPPPNNN----------------SSSSSSNNSASAAA Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE SI------TSRHSQ--SSRSPPVAS----------------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------HGLPPMQ----------------------------QCAP--- Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE S-------ASGDSQPINYRSPPDS------------------------------------ Ptychodera-flava_PF10086-t1_NONE -------------------MFPKL------------------------------------ Ptychodera-flava_PF18712-t1_NONE ------------------HGL-QMQ----------------------------QCVS--- Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE -------RLENPGIVGRQSVRPKIK----------------------------------- Acanthaster-planci_oki169-35_NONE L---------------QLVPTPISP----------------------------------- Acanthaster-planci_oki20-22_NONE S---------RYAFDNHFHPSPELA----------------------------NFSTP-- Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte SLHDFNAHHDSDGNSQRCYPFPSLQ-------------------------NQQQQQSN-- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ------------------FHLPKF------------------------------------ Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------AAFPF-P----------------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like T---------------GGYTPPDSN----------------------------SSRS--- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -------------------AFPF-P----------------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo S---------------GGYTPPDSN----------------------------SSRS--- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ---------------YTEQTSPETE--------------------NQAYTSAENAQQD-- Oikopleura-dioica_GSOIDT00006159001_NONE --------------------FPTYNFCNDT----------------T------------- Oikopleura-dioica_GSOIDT00004289001_NONE S---------------PFGAFPFPA----------------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE ------------------SDLPFF------------------------------------ Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------ASSPYMS----------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE ------------------SDLPFF------------------------------------ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------REMPYAR----------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin --------------PDGRKTTPC--GEEELPPAAA------------ARYSMDSLSPE-- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -------------DVQRNKLSPVLDGVSEL------------------RHSFDGSAAD-- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------ADPQHRYFYPE-PGAQDA----------------DERRGGGSLGS--- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------PPDGRKGSPC--GEEELPSAAAAAAAAAAAAAATARYSMDSLSSE-- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc -------------DVQRSKLSPVLDGVSEL------------------RHSFDGSAAD-- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 370 380 390 400 410 420 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------EARV--------SPSIIVPK-DLK Pinctada-fucata_pfu930-101250t1_NONE ---------------------------------------------QSASRAPLTPG-DLI Pinctada-fucata_pfu5110-102705t1_NONE ------------------------------------------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------P----- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------RKQIITK----------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -------------GAGVGGPGA------------------------GGPPPNLFFS-MLQ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 HPSHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPA-AAL Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------------------T----------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF10086-t1_NONE ----------------------------------------------GDPRCHYAP--DLL Ptychodera-flava_PF18712-t1_NONE -----------------------------------------------------------G Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ------------------------------------------------RPTGVLPD---- Acanthaster-planci_oki169-35_NONE ------------------------------------YSRVAQQGSAQSAPSSPTPH-GTV Acanthaster-planci_oki20-22_NONE ------------------------------------------------PVPNYHPY---- Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte -----------------------------------------------------LPQYLLN Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----------------------------------------------GEHPAAYSPH-DLL Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ----------------------------------------SFPMTQAAPAPPPDP----- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ----------------------------------------GFPMAQAAPAPPPDP----- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ------DQTYHT------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE --------AHRS------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE -------------------------------------------------PPSYFPN-LSM Ciona-savignyi_ENSCSAVT00000020041.1_NONE ----------------------------------------SNDRLHG------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE -------------------------------------------------PPSYLPS-LSM Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ----------------------------------------NLQRPRGAPL---------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---------------------------------RYYLQSPGPPVAELGGPCALFP----- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ---------------------------------RYLLSQSSQPQSAASAPSAMFP----- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------------------------------------------------P----- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---------------------------------RYYLQSPGPQGSELAAPCSLFP----- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ---------------------------------RYLLSQSSQPQSAATAPSAMFP----- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ---------------------YACL-------QPMGTQSRI----GELSYSLPYSQN--- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 -----------------------AH-------DPMGLTSQS----Q---QFGGYPP---- Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE DAIPVPKEDI-----------S-KT-------EPET------------------------ Pinctada-fucata_pfu930-101250t1_NONE H----------------------PF-------HP-------------------------- Pinctada-fucata_pfu5110-102705t1_NONE ---------------------YACL-------QPVTQVHRQ----DAHGYQESYTQQDT- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 AG-------------------F-PP-------GPVGS----------------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 AALAGSPAGPHPGLYPGGGLRFPPH-------HP-GAHPHA----HH--LGSAYTTAE-- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE -----------------------LM-------APNAGNYIL----GK------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE EHLTFTDRRS---------------------------------------HFENFAS---- Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ----------------------------------NSGATYL----HN------------- Ptychodera-flava_PF10086-t1_NONE S----------------------VH-------QP-G------------------------ Ptychodera-flava_PF18712-t1_NONE DHLAFSDRGR---------------------------------------HFGDFPP---- Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ----------------ERGVSFGSE-------PDVGSISPK------------------- Acanthaster-planci_oki169-35_NONE TAATLPHRPA-----------F-TL-------DPSRS----------------------- Acanthaster-planci_oki20-22_NONE ------------------HHQYPLHSPLHHFQQPRGGSIYQPDSLNLSEYPEAAPSNPSN Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte TNCTLSNFTS-----------IPTP-------PPATSHSQQVR-LGAAPYADGFQHLSQT Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara AA-------------------------------------HA----H-------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like --CAFSDR-----------------------------------------FATDFH----- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ---------------------SPGD-------GVDAELSR-------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like --CAFSDR-----------------------------------------FATDFH----- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ---------------------SPGD-------GVDAELSR-------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ---------------------YYTS-------QPVYQTTEN---DAAQVYQTVYPTPD-- Oikopleura-dioica_GSOIDT00006159001_NONE ---------------------Y-------------------------------------- Oikopleura-dioica_GSOIDT00004289001_NONE ---------------------F-LG-------TPSG-------------AFAGFPR---- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------M-------GPTGINPIN----EH-MFSNIFSR---- Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE THCASS-----------------LM-------FPKGANSVA----G---LGSAFDRG--- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ----YSDS-----------------------------------------YISKFNPIL-- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE AHCAPS-----------------LM-------FPKGANSIA----G---LGSAFERS--- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri --LEQSNP-----------------------------------------YISKFDSNP-- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---------------------YPPA-------AQHGAVYQA---PGGPRY---------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ---------------------YP---------GQHGPAHPAFSIASPSRYMAHHPVI--- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------------------YP-----------GGALVPA----PPSRFLGAY------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---------------------YQAAA-----GAPHGPVYPA---PNGARY---------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ---------------------YP---------GQHGPAHPAFSIGSPSRYMAHHPVI--- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 490 500 510 520 530 540 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------NGYGFEMD-QMHYYSNVS---YPQSAQHQPVSSPVHLPPPNT Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 --------------------LSSHSDHK-------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein -----------------------AVDSEMT------------------------------ Pinctada-fucata_pfu26-120078t1_NONE -------------------------DHDEVS----------------------------- Pinctada-fucata_pfu930-101250t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu5110-102705t1_NONE ---------------YKYNGYMPQVDPNMMYYGGNY---NAQPAQH--TQQQQQMPSGNN Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa -------------------------D---------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN --------------------LPIPMPR---HVI--------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN --------------------LPFNMPHQQPHMM--------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -----------------DVVLASAVAHQLHP----------------------------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -----------------------AVDPTTGLSGNVS---G-------------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE --------------------GGPA-NIGLANL---------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE --------------------LSGAGDLKSHHML--------------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE -----------------------AVQSEMN------------------------------ Ptychodera-flava_PF12118-t1_NONE --------------------KLPAPNISLLN----------------------------- Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE --------------------LPGHMDHKPQHMM--------------------------- Ptychodera-flava_PF18670-t1_NONE -----------------------AVQTEMN------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ------------------ENRRRPEDMRLLLGADYM------------------------ Acanthaster-planci_oki169-35_NONE -----------------------PLDPGEAS----------------------------- Acanthaster-planci_oki20-22_NONE PGSHCFLPAGCSSPKVPSSNCSSPVEFEDLSLN--------------------------- Acanthaster-planci_oki15-190_NONE -----------------------AVQSEMT------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte NQAH----------RQISEIETPSVNDALNHGTGFTLHCNSQTTSSGCSNTDDKLSTSAN Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara -----------------------------RS----------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte -----------------------AVQSEMN------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ----------------------MTADHKTQRLG--------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like -----------------YNSQVPP-DYPLGPYPGA----NPENAYSITSMTPSPHPYPNG Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -----------------------AVESEIS------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -----------------------AVESEIS------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ----------------------MTADHKTQRLG--------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo -----------------YNSQVPP-DYPLGHYPGAT---NPENAYSITSMTPSPHPYTNG Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -----------------------AVESEIS------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -----------------------AVESEIS------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE --------------------RSSSEDSEEHE---------------------------DR Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE -----------------------LQHPQIPQIP--------------------------- Oikopleura-dioica_GSOIDT00000279001_NONE -----------------------PLDIKIE------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE --------------------LCGTQAHDLPQ----------------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE -----------------GNEAIISVNEQ-------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE -----------------------TLESCL------------------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE --------------------LCGAQGHDLPQ----------------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -----------------NSGSILTVDSS-------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript -----------------------S-DSKLA------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -----------------------PYGSVL------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 --------------------TNGAYNSLLS------------------------------ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -----------------------VVESELR------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -----------------------AVESELQ------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -----------------------AYPPRP------------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -----------------------PYGSML------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc --------------------TNGAYNSLLS------------------------------ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -----------------------VVESELQ------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -----------------------AVENELQ------------------------------ 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 -------------------------------------------------EPALAPI-QSS Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ---------------------------------------------------------RML Crassostrea-gigas_EKC28765_Brachyury-protein -----------------------------------------------------VGS-EKG Pinctada-fucata_pfu26-120078t1_NONE ---------------------------------------------------------TTT Pinctada-fucata_pfu930-101250t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu5110-102705t1_NONE -------------------------------------------------TSCVSPN-GQS Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 -ER------------------------------------------------------SRG Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -----------------------------------------------------MPP-RVT Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -----------------------------------------------------LPS-RPT Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ----------------------------------------------------------AM Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -------GGG--------------------------------------GGGAGGGA-GSG Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------------------------------------------------------PSS Saccoglossus-kowalevskii_Sakowv30012255_NONE -----------------------------------------------------SG---GG Saccoglossus-kowalevskii_Sakowv30011577_NONE -----------------------------------------------------DCT-KKG Ptychodera-flava_PF12118-t1_NONE ----------------------------------------------------------AS Ptychodera-flava_PF10086-t1_NONE -----------------------------------------------------------L Ptychodera-flava_PF18712-t1_NONE -----------------------------------------------------AG---TG Ptychodera-flava_PF18670-t1_NONE -----------------------------------------------------DCS-KKG Acanthaster-planci_oki84-25_NONE ---------------------------------------------------------SAP Acanthaster-planci_oki58-6_NONE ---------------------------------------------------------LTG Acanthaster-planci_oki169-35_NONE ---------------------------------------------------------PGA Acanthaster-planci_oki20-22_NONE ---------------------------------------------------------SKT Acanthaster-planci_oki15-190_NONE -----------------------------------------------------RGS-EKG Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte HNQIQQHLQQQQQPLQEFDMKKELEHGGIHAPPFFVENTPPLHQTTNTLPQQLIGG-SLG Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----------------------------------------------------------AL Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte -----------------------------------------------------RGS-EKG Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like -----------------------------------------------------L----GH Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like YEQPQMYGQQ--------------------------------------PPGYFAPITDSG Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -----------------------------------------------------AGS-EKG Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -----------------------------------------------------AGS-EKG Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -----------------------------------------------------L----GH Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo YDQPQMYGQQ--------------------------------------PPGYFAPI-ESG Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -----------------------------------------------------AGS-EKG Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -----------------------------------------------------AGS-EKG Oikopleura-dioica_GSOIDT00014261001_NONE KEQKE------------------------------------------------SENTQSA Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE -----------------------------------------------------------S Oikopleura-dioica_GSOIDT00007455001_NONE -----------------------------------------------------KKE-EEK Oikopleura-dioica_GSOIDT00000279001_NONE -----------------------------------------------------------D Ciona-savignyi_ENSCSAVT00000016577.1_NONE ----------------------------------------------------------SK Ciona-savignyi_ENSCSAVT00000020041.1_NONE -----------------------------------------------------------H Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------MT-GQN Ciona-intestinalis_ENSCINT00000017704.3_NONE ----------------------------------------------------------GK Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -----------------------------------------------------------H Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript -----------------------------------------------------GMT-SSE Botryllus-schlosseri_botctg005874g48703_NONE -----------------------------------------------------GGQ-LRA Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------------------------------------------------S-SGG Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -----------------------------------------------------NSS-PQG Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 -----------------------------------------------------------K Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -----------------------------------------------------AGR-DKG Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -----------------------------------------------------AGS-EKG Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -------------------------------------------------------Q-AAG Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------------------------------------------------P-PGG Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc -----------------------------------------------------NSS-PQG Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio -----------------------------------------------------------K Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -----------------------------------------------------AGR-EKG Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -----------------------------------------------------AGS-EKG 610 620 630 640 650 660 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 PPAVPSGS-------------------------------FS------------------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 GPA--------------------------------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein DPT--------------------------------------------------------- Pinctada-fucata_pfu26-120078t1_NONE SPA--------------------------------------------------------- Pinctada-fucata_pfu930-101250t1_NONE RPL--------------------------------------------------------- Pinctada-fucata_pfu5110-102705t1_NONE N---GQGR-------------------------------FQQN----------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 RPK-------------------------IG-------LKMKEG----------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN LPG--------------------------------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN LPG--------------------------------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 RPL--------------------------------------------------------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI SPQHVTHNG----------------------------HGHGHG-LGG---VAAVS----- Saccoglossus-kowalevskii_Sakowv30002752_NONE SPTSYSNQL----------------------------ANFERS-YGS---SQC------- Saccoglossus-kowalevskii_Sakowv30012255_NONE PPT--------------------------------------------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE DPT--------------------------------------------------------- Ptychodera-flava_PF12118-t1_NONE SPTEFQSQY----------------------------INMDTAGYGN---QQATF----- Ptychodera-flava_PF10086-t1_NONE RPV--------------------------------------------------------- Ptychodera-flava_PF18712-t1_NONE HPT--------------------------------------------------------- Ptychodera-flava_PF18670-t1_NONE DPN--------------------------------------------------------- Acanthaster-planci_oki84-25_NONE GPGKGHGRT------------------------------------------------CCI Acanthaster-planci_oki58-6_NONE HPAPVRDSPD--------KDAGP-LSGRHGSAAS--VMETNEG----------------- Acanthaster-planci_oki169-35_NONE GPGAGD------------------------------------------------------ Acanthaster-planci_oki20-22_NONE RPAAGPRGLE----------------------------------LAGV-PSFPIPGAEQC Acanthaster-planci_oki15-190_NONE DPS--------------------------------------------------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte PPS----------------------SHSFG-------HHHNRASHGQEDENAKSHLSSHI Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara GPL--------------------------------------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte DPS--------------------------------------------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like LP---------------------------------------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like PPQAPNGQ-------------------------------YPQG-YNG---NYPYP----- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform DPT--------------------------------------------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform DPT--------------------------------------------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like LP---------------------------------------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo PPQPPNGQ-------------------------------YQHG-YNG---NYPYP----- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo DPT--------------------------------------------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo DPT--------------------------------------------------------- Oikopleura-dioica_GSOIDT00014261001_NONE HPD-----------------------------------------------MASIA----- Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE QPALP------------------------------------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE KP---------------------------------------------------------- Oikopleura-dioica_GSOIDT00000279001_NONE APSE-------------------------------------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE LP---------------------------------------------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE PPDFANAI---------------------------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE TNE--------------------------------------------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE LP---------------------------------------------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri PPNLSGGI---------------------------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript SIE--------------------------------------------------------- Botryllus-schlosseri_botctg005874g48703_NONE APDEAYAR-----------------------------RDLAQC----------------- Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin FAGAVCP-PGGRTQF--------------GGGGG---YQYGQA-AAG----GALYG---- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 YPAPGYPYP----------------------------QQYGHS-YQG----APFY----- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 APT--------------------------------------------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 DPT--------------------------------------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra DPT--------------------------------------------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti FPGAGESFP-------PPADA-------EG-------YQPGEG-YAAPDPRAGLY----- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin FPAAVCP-P-GRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQ----G----APLYG---- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc YPTAGYPYP----------------------------QQYGHS-YQG----APFY----- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio SPS--------------------------------------------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti DPT--------------------------------------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio DPT--------------------------------------------------------- 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 -----------------------------------PCIYLCNRDLWIKFHQ--------H Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------MEPEPDA-QDDPKVEIESKELWEQFHN--------L Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ---------------------------QGDTMDKNIKITLENRDLWSKFHS--------I Crassostrea-gigas_EKC28765_Brachyury-protein --------------------------------ERQLKVNLEDKELWGKFKE--------F Pinctada-fucata_pfu26-120078t1_NONE ----------------------------CSRELAGIQCRLETKDLWDKFHE--------L Pinctada-fucata_pfu930-101250t1_NONE ----------------------RVLEPESDA-QDDPKVEIESKELWEQFHK--------F Pinctada-fucata_pfu5110-102705t1_NONE ----------------------------------KACIQLCNAELWARFHQ--------H Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 --------------------------------NLPIECKLEGSELWAKFFD--------L Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ---------------------------NC----KFIRVFLQSSNLWRRFHN--------L Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -------------------------PPEDDGVTDDPKVELDERELWQQFSQ--------C Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -----------------------------------VEMTLQNDDLWKQFHQ--------I Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -----------------------------------VEAKLENNDLWQQFHK--------I Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ----------------------RALQPEDDGVVDDPKVTLEGKDLWEKFHK--------L Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI --------GGGASVSGNGGHRVVGGAGSPNELDRNLRISLDDRELWLRFQN--------L Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------YQSSTSN------SM-----ANSYNKACVYLCNRDLWLKFHQ--------H Saccoglossus-kowalevskii_Sakowv30012255_NONE -------------------------IPHTVVQNKDIKVNLEGKELWTKFHE--------I Saccoglossus-kowalevskii_Sakowv30011577_NONE --------------------------------ERHVKISLEDVELWKRFGN--------L Ptychodera-flava_PF12118-t1_NONE --------THGSPTFN------GLRQPNTAGFKGKACVYLCNRDLWLKFHQ--------Q Ptychodera-flava_PF10086-t1_NONE ----------------------RAVENQPDE-DENIQVNLDTKELWEEFHK--------R Ptychodera-flava_PF18712-t1_NONE -------------------------IPPTTVQNKDIKVTLEGKELWEKFHK--------I Ptychodera-flava_PF18670-t1_NONE --------------------------------ERNVKISLEDAELWKRFEN--------L Acanthaster-planci_oki84-25_NONE V----------------------------------LGAFIRLLHFW--FSNLLSVV---L Acanthaster-planci_oki58-6_NONE ---------------------GLLLDEPISQCVDGIQVTLENSRLWKMFDK--------C Acanthaster-planci_oki169-35_NONE ----------------------ADKGSNCIDEMSAVRCRLETRELWEKFHE--------L Acanthaster-planci_oki20-22_NONE LQEPSPQSERLSPEQQV-----PTVGSSPPSGFTKASVFLCNSELWRKFHE--------H Acanthaster-planci_oki15-190_NONE --------------------------------EKGLKVTLEDRDLWRRFSK--------L Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte VSQPYPP-------------PAGHQHVEVANGPGKASVYLCNRDLWRKFHQ--------H Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----------------------HPMETQSDD-SDDPQVTLESKELWEKFHK--------R Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte --------------------------------EKGLKVRLDDVELWKKFHK--------L Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ----------------------APQNFPPPSALKDMKVTLEQKDLWDSFHD--------I Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like --------GGGSM---------YGYPPGPPPPPAKLSVFLTNRDLWVKFHQ--------H Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform --------------------------------ERDLKVTLGEKPLWEKFKS--------L Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform --------------------------------ERDLKISLEEKPLWDKFNA--------L Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ----------------------APQNFPPPSALKDMKVTLEQKDLWDSFHD--------I Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo --------GGGSM---------YGYPPGPPPTPAKLSVFLTNRDLWVKFHQ--------H Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo --------------------------------ERDLKVTLGEKPLWEKFKS--------L Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo --------------------------------ERDLKITLEEKPLWDKFNA--------L Oikopleura-dioica_GSOIDT00014261001_NONE ----------------------YISSQNGPEVVDGISMELDKRDLWRTFYR--------Y Oikopleura-dioica_GSOIDT00006159001_NONE ----------------------GNIEISTQQNDPNLSVKLAERDLWDSFDKTFIYRYFQV Oikopleura-dioica_GSOIDT00004289001_NONE ----------------------GLQRQNHRVFDEDIKAELDEKHLWDDFHK--------I Oikopleura-dioica_GSOIDT00007455001_NONE -------------------------DNEDDDGPDNAKVNLENMDLWDSFHQ--------F Oikopleura-dioica_GSOIDT00000279001_NONE --------------------------------ADQIEVKLEEEPLWNKFSN--------L Ciona-savignyi_ENSCSAVT00000016577.1_NONE -------------------------D-PDDNEPDDPQVDLDNMELWEQFHR--------R Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------PFQSSTQGTSQSPAEPNLQVELCDRELWQEFSN--------V Ciona-savignyi_ENSCSAVT00000003855.1_NONE --------------------------------SSCVKMSLVDQNLWSRFHA--------F Ciona-intestinalis_ENSCINT00000017704.3_NONE -------------------------D-PDDNEPDDPQVDLDNMELWEQFHR--------R Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------YRQHSFTNAPTLNSDANLKVELCDRKLWQEFSN--------V Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------KVHLEDWKLWEQFSA--------V Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript --------------------------------TCAVKMALIEHGLWSRFHA--------F Botryllus-schlosseri_botctg005874g48703_NONE ------R-------------------------ESAVRITLCDQALWNQFNS--------I Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---PYP--PASGSCGGL-----GALGVPAAGPGLRAQVFLCNRPLWLKFHR--------H Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 --------QFSSAQPGL---------VP--G---KAQVYLCNRPLWLKFHR--------H Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ----------------------SPQAAFTQQGMEGIKVFLHERELWLKFHE--------V Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 --------------------------------EKQLQVVLEDAPLWQRFRE--------V Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra --------------------------------ERELRVALEDGELWLRFKE--------L Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---PGPR-EDYALPAGL--------EVS--G---KLRVALNNHLLWSKFNQ--------H Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---PYPGAAAAGSCGGL-----GGLGVP--GSGFRAHVYLCNRPLWLKFHR--------H Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc --------QFSSTQPGL---------VP--G---KAQVYLCNRPLWLKFHR--------H Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ----------------------SPQAAFTQQGMEGIKVFLHERELWLKFHE--------V Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti --------------------------------EKQLQIILEDAPLWQRFKE--------V Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio --------------------------------ERELRVGLEESELWLRFKE--------L 730 740 750 760 770 780 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 TTEMIITKQG--------RRMFPTLQFSLNGLDPHKQYNVFVDMILADPH----HWKFQN Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 GTEMVITKSG--------RRMFPPYKVRVSGLDKRAKYILLMDIVAVDDC----RYKFHN Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 GTEMIITKTG--------RRMFPTLKVNLEGLDPHSKYILLIDIVPVDDC----RYKYHN Crassostrea-gigas_EKC28765_Brachyury-protein TNEMIVTKNGRQVFIRGRRRMFPVFKVSISGLDPNSMYTLLLDFVQVDTH----RWKYVN Pinctada-fucata_pfu26-120078t1_NONE GTEMIITKTG--------RRMFPTLRVSFTGIDPEVRYMVLMDIVPVDNKRY--RYAYHR Pinctada-fucata_pfu930-101250t1_NONE GTEMVITKSG--------RRMFPPFKVRVSGLDKRAKYILLMDIVAVDDC----RYKFHN Pinctada-fucata_pfu5110-102705t1_NONE TTEMIITKQG--------RRMFPTLQFSLAGLDPHKQYNVFVDMILADPN----HWKFQS Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 GTEMIITKSG--------RRMFPTVKVSFTNVILDALYYIFLDVVPVDSKRY--RYIYNK Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa GTEMIVTKSG--------RRMFPTLSVIIAGLDPVKSYVVMVDLECIEMKRF--RYSFHQ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 GTEMVITKSG--------RRIFPAYRVKISGLDKKSQYFVMMDLVPADEH----RYKFNN Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN GTEMIITKSG--------RRMFPSMRLSVSGLEDESNYCVLLEMVPIGDC----RYKFSG Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN GTEMIITKSG--------RRMFPSMRVSLSGLEEEASYCVLLEMVPIGDC----RYKFSG Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 GTEMVITKSG--------RQMFPQMKFRVSGLDAKAKYILLLDIVAADDY----RYKFHN Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI TNEMIVTKNG--------RRMFPVVKISASGLDPAAMYTVLLEFVQIDSH----RWKYVN Saccoglossus-kowalevskii_Sakowv30002752_NONE NTEMIITKQG--------RRMFPTLSFRFTGLDQTAHYNVFVDMVLSDPN----HWKFQS Saccoglossus-kowalevskii_Sakowv30012255_NONE GTEMIITKAG--------RRMFPTFRASVTGLDPHAKYIMLMDIVPVDDT----RYKYHN Saccoglossus-kowalevskii_Sakowv30011577_NONE TNEMIVTKNG--------RRMFPVLRISISGLDPNAMYSVLLDFVAADNH----RWKYVN Ptychodera-flava_PF12118-t1_NONE NTEMIITKQG--------RRMFPTLSFRFTGLDPSAHYNVFVDMVLSDPN----HWKFQS Ptychodera-flava_PF10086-t1_NONE GTEMVITKSG--------RRIFPAYKVRVSGLDKKAKYILLMDIVAADDC----RYKFHN Ptychodera-flava_PF18712-t1_NONE GTEMIITKAG--------RRMFPTFRASVSGLDPHAKYIMLMDIVPVDDT----RYKYHN Ptychodera-flava_PF18670-t1_NONE TNEMIVTKNG--------RRMFPVLRVSISGLDPNAMYSVLLDFVASDNH----RWKYVN Acanthaster-planci_oki84-25_NONE KPAGLMTAIG-------SRRMFPTFQVKISGMDPMAEYILMMDFVPVDDKRY--RYAFHS Acanthaster-planci_oki58-6_NONE GTEMIVNRIG--------RRMFPCIVTAIRGMDATAMYRVQMELDASDRR----RYKFIN Acanthaster-planci_oki169-35_NONE GTEMIITKTG--------RRMFPTVRVSFSGVAAEARYVVMLDIVPLDNKRY--RYAYHR Acanthaster-planci_oki20-22_NONE RTEMIITKQG--------RRMFPQLVFRLSGLNPTTHYNVFVDMVLADQN----AWKFQC Acanthaster-planci_oki15-190_NONE TNEMIVTKSG--------RRMFPVLSASVTGLNPNAMYSILLDFTPADEH----RWKYVN Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte KTEMIITKQG--------RRMFPQLVFKLTGLNPTSQYNVFVDMVLCDPN----QWKFQC Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara GTEMVITKSG--------RRMFPSFKVRVSGLDKKAKYILLMDIVAADDC----RYKFHN Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte TNEMIVTKSG--------RRMFPVLSASIAGLDPNSMYSVLLDFSAADDH----RWKYVN Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like GTEMIITKAG--------RRMFPTYKASISGLDPNAKYILLMDIVPMDDN----RYKYHN Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ETEMIITKQG--------RRMFPVLQFAISGLDPHAQYNVFVDMVLADVN----HWKFQN Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform TNEMIVTKSG--------RRMFPVLKVNVSGLDPNAMYSFLLDFTAADNH----RWKYVN Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform TNEMIVTKNG--------RRMFPVLKVNVSGLDPNAMYSFLLDFTAADNH----RWKYVN Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like GTEMIITKAG--------RRMFPTYKASISGLDPNAKYILLMDIVPMDDN----RYKYHN Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ETEMIITKQG--------RRMFPVLQFAISGLDPHAQYNVFVDMVLADVN----HWKFQN Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo TNEMIVTKSG--------RRMFPVLKVNVSGLDPNAMYSFLLDFTAADNH----RWKYVN Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo TNEMIVTKNG--------RRMFPVLKVNVSGLDPNAMYSFLLDFTAADNH----RWKYVN Oikopleura-dioica_GSOIDT00014261001_NONE GTEMIITKVG--------RRMFPSMKVSVNGLDPQKTYAMILDILPVDDSRY--RYVYNS Oikopleura-dioica_GSOIDT00006159001_NONE GTEMIITKTG--------RRMFPGIKVNISGMEAHENYVVILDFANVDEK----RYKFSD Oikopleura-dioica_GSOIDT00004289001_NONE GTEMVITKNG--------RRMFPSFKAKVSGLDPRANYVMMVDMVPVDEN----RYKFHN Oikopleura-dioica_GSOIDT00007455001_NONE GTEMVITKTG--------RRMFPSYKTRVTGLNPKAKYCMLMDISAADEPSLSRRYKYHN Oikopleura-dioica_GSOIDT00000279001_NONE TNEMIVTKNG--------RRMFPVMKVRTKGLDENAMYTVLLDFTAADNH----RWKYVN Ciona-savignyi_ENSCSAVT00000016577.1_NONE GTEMVITKTG--------RRMFPSFKVKVSGLSKSAKYIMLMDIVAADDC----RYKFHN Ciona-savignyi_ENSCSAVT00000020041.1_NONE GTEMIVTKAG--------RRMFPGYRVKISGMDPNTQYCVLMDIVNVDEH----RYKFQQ Ciona-savignyi_ENSCSAVT00000003855.1_NONE VNEMIVTKNG--------RRMFPVLKTTISGLDPTAMYSVMLDFVAVDNN----RWKYVN Ciona-intestinalis_ENSCINT00000017704.3_NONE GTEMVITKTG--------RRMFPSFKVKVSGLSKTAKYIMLMDIVSADDC----RYKFHN Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri GTEMIVTKAG--------RRMFPGYRVNISGMEPDANYCVMMDIVNVDEH----RYKFQQ Ciona-intestinalis_ENSCINT00000034896.1_NONE QTEMIVTKTG--------RRMFPGYRVKMSGMDPNAQYCVLMDISSVDEN----RYKFQH Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript VNEMIVTKNG--------RRMFPVLKTSITGLDPTAMYSVMLDFVPVDNN----RWKYVN Botryllus-schlosseri_botctg005874g48703_NONE GTEMVLNKVG--------RRIFPSFRVTFSGLEPCARYKIMMDVERVDEN----RYKFQD Botryllus-schlosseri_botctg007226g53212_NONE --------------------MFPSXKVKVTXLNKNAKYIMLMDIVAADDC----RYKFHN Botryllus-schlosseri_botctg002459g63408_NONE ---MIVTKSG--------RRMFPVLKVTATGLEPTSMYSFHLYFASSDLH----RWKYVN Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin QTEMIITKQG--------RRMFPFLSFNITGLNPTAHYNVFVEVVLADPN----HWRFQG Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 QTEMIITKQG--------RRMFPFLSFNISGLDPTAHYNIFVDVILADPN----HWRFQG Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 GTEMIITKAG--------RRMFPSYKVKVTGLNPKTKYILLMDIVPADDH----RYKFAD Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 TNEMIVTKNG--------RRMFPVLKISVSGLDPNAMYSFLLDFAPTDGH----RWKYVN Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra TNEMIVTKNG--------RRMFPVLKVSVSGLDPNAMYSFLLDFVAADGH----RWKYVN Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti QTEMIITKQG--------RRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQH----HWRYQS Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin QTEMIITKQG--------RRMFPFLSFNINGLNPTAHYNVFVEVVLADPN----HWRFQG Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc QTEMIITKQG--------RRMFPFLSFNISGLDPTAHYNIFVDVILADPN----HWRFQG Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio GTEMIITKAG--------RRMFPSYKVKVTGLNPKTKYILLMDIVPADDH----RYKFAD Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti TNEMIVTKNG--------RRMFPVLKISVTGLDPNAMYSLLLDFVPTDSH----RWKYVN Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio TNEMIVTKNG--------RRMFPVLKVNVSGLDPNAMYSFLLDFVAADNH----RWKYVN 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 GKWVPCGQAEQLSQNGRVYLHPDSPSSGAHWMKQ-DIVFGKLKLTNN-RALDQ-GQVSQI Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 SRWMVAGKADP-EMPKRMYIHPDSPSTGEQWMQK-VVSFHKLKLTNN-ISDKH-GY---T Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 SEWVVTGKAEP-HMPGRLYIHPDSPASGSHWMKQ-PMSFHKLKLTNN-NLDQN-GH---I Crassostrea-gigas_EKC28765_Brachyury-protein GDWVAGGKAEP-AAPNCVYIHPDSPNFGAHWMKE-TVSFSKVKLTNK-LNG-G-G---QI Pinctada-fucata_pfu26-120078t1_NONE SSWLVAGKADP-PLPTRLYMHPDSPYTGEQLQKQ-TVSFEKLKLTNN-MLDKN-GH---I Pinctada-fucata_pfu930-101250t1_NONE SRWMVAGKADP-EMPKRMYIHPDSPSTGEQWMQK-VVSFHKLKLTNN-ISDKH-GY---T Pinctada-fucata_pfu5110-102705t1_NONE GKWVPCGQAEQLPQVGRVYLHPDSPSSGSHWMKQ-YIVFGKLKLTNN-RNNDQ-G---HI Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 SAWLTAGKAEP-VPKNRYYLHPDSPFTGDQLLKH-VISFEKTKLTNN-EVDKT-GH---L Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa SKWISTGPGES-ELPSRMFVHTDSPARGAHWMRA-PVSFDKMKLTNN-QLDNN-GH---I Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 SRWMIAGKADP-EMPKTLYIHPDSPSTGEHWMSK-GANFHKLKLTNN-ISDKH-GY---T Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN SQWVPAGGAEP-QSPQRMYLHPDSPATGAHWQAQ-PILFNKVKLTNN-TLDNS-GH---I Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN SQWVPAGGAEP-QSPQRMYLHPDSPATGAHWQSQ-ALLFNKVKLTNN-TLDSS-GH---I Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 SRWMVAGKADP-EMPKRMYIHPDSPTTGEQWMQK-VVSFHKLKLTNN-ISDKH-GFVSTT Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI GEWVPGGKAEV-PPSNPIYVHPESPNFGAHWMKE-PISFAKVKLTNK-TNG-N-G---QI Saccoglossus-kowalevskii_Sakowv30002752_NONE GKWVPCGQAEHVHPGSNIYIHPDSPNTGSHWMKQ-EVVFGKLKLTNN-KGKEH-GH---I Saccoglossus-kowalevskii_Sakowv30012255_NONE SEWVVTGKAEP-HMPGRLYIHPDSPATGAVWMKQ-VVSFHKMKLTNN-NLDQH-GH---I Saccoglossus-kowalevskii_Sakowv30011577_NONE GEWVPGGKPEA-AAPSSVYIHPDSPNFGAHWMKQ-SVNFSKVKLTNK-LNG-G-G---HI Ptychodera-flava_PF12118-t1_NONE --------------GSNIYIHPDSPNTGNHWMKQ-EVVFSKLKLTNN-KGKDN-GH---I Ptychodera-flava_PF10086-t1_NONE SRWMVAGKADP-EMPKRMYIHPDSPCTGEQWMQK-LVSFHKLKLTNN-ISDKH-GY---T Ptychodera-flava_PF18712-t1_NONE SEWVVTGKAEP-HMPGRLYIHPDSPATGAVWMKQ-VVTFHKMKLTNN-NLDQH-GH---I Ptychodera-flava_PF18670-t1_NONE GEWVPGGKPEA-AAPSSVYIHPDSPNFGAHWMKQ-AISFGKVKLTNK-LNG-G-G---HI Acanthaster-planci_oki84-25_NONE SSWLVAGKADP-EMPGRIHVHPDSPARGAMWMKQ-IVSFDKLKLTNN-LLDDN-GH---I Acanthaster-planci_oki58-6_NONE GKWLPVGKADP-ETSNQPFEHPDSPNLGAFWMQD-RVSFAKLKITNNKEGG---GD--NT Acanthaster-planci_oki169-35_NONE SSWLVAGKADP-PLPPRLYVHPDSPFTGDQLQRQ-MVSFEKVKLTNN-EQDQH-GH---I Acanthaster-planci_oki20-22_NONE GKWVATGKSDGVPRATGIYKHPDSPNTGEHWMRQ-DIAFSKLKLTNN-RGKDS-GY---L Acanthaster-planci_oki15-190_NONE GEWVPGGKPDS-PPPSTAYIHPDSPNFGAHWMKQ-CVSFSKVKLSNK-LNG-T-G---QI Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte GKWIPCGQAENIPKVSNIYLHPDSPSNGLHWMHQ-DIVFSKLKLTNH-RAKDN-GF---V Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara SRWMVAGKADP-EMPKRMYIHPDSPSTGEQWMQK-CVSFHKLKLTNN-ISDKH-GF--QT Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte GEWIPGGKPDG-SPPTTAYIHPDSPNFGAHWMKQ-AVNFSKVKLSNK-LNG-S-G---QV Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like SEWVVSGKAEP-LMPGRLYIHPDSPATGTQWMKQ-SVTFHKLKLTNN-AMDQQ-GH---I Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like GKWVPCGRADTNPQGSRVYVHPESPNSGAHWMKQ-EVVFSKLKLTNN-KGADN-G---HV Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform GEWVPGGKPEP-SVPSCVYIHPDSPNFGAHWMKS-PVSFSKVKLTNK-LNG-G-GQ--QI Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform GEWVPGGKPEP-SVPSCVYIHPDSPNFGAHWMKS-PVSFSKVKLTNK-LNG-G-GQ--QI Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like SEWVVSGKAEP-LMPGRLYIHPDSPATGTQWMKQ-SVTFHKLKLTNN-AMDQQ-GH---I Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo GKWVPCGRADTNPQGSRVYVHPESPNSGAHWMKQ-EVVFSKLKLTNN-KGADN-G---HV Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo GEWVPGGKPEP-SVPSCVYIHPDSPNFGAHWMKS-PVSFSKVKLTNK-LNG-G-GQ--QI Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo GEWVPGGKPEP-SVPSCVYIHPDSPNFGAHWMKS-PVSFSKVKLTNK-LNG-G-GQ--QI Oikopleura-dioica_GSOIDT00014261001_NONE SKWVSVGNADT-NLPERVYVHPESPQKGSDWMRS-LVNFDKLKLTNN-ENDTK-GQ---I Oikopleura-dioica_GSOIDT00006159001_NONE GEWKLGGRCEP-NHPKRFFIHPDSPNTGSHWQQK-TISFRGAKLTNNLVSDPN-----MI Oikopleura-dioica_GSOIDT00004289001_NONE GRWLVAGKADP-EMHPRMFIHPDSPCSGSHWMSRPNISFHKMKLTNN-ISDRS-GS---T Oikopleura-dioica_GSOIDT00007455001_NONE TRWMVAGKADP-ELPKRMYVHPDSPATGEQWMNRPCISFHKLKLTNN-ITDPH-GH---T Oikopleura-dioica_GSOIDT00000279001_NONE GEWVPGGKPEP-QVPSSVYMHPDSPNFGSHWMKQ-PLSFSKVKLTNK-LNQHN-GQ--QI Ciona-savignyi_ENSCSAVT00000016577.1_NONE SRWMVAGKADP-ELPKRMYIHPDSPATGVQWMNRPGVSFHKLKLTNN-IADPH-GH---T Ciona-savignyi_ENSCSAVT00000020041.1_NONE GEWMVAGKGEL-HAPQRMFLHSDSPATGSKWMTD-IVSFYKIKLTNS-INGRSTDK---I Ciona-savignyi_ENSCSAVT00000003855.1_NONE GEWVPGGKPEP-HVTSCAYIHPDSPNFGSHWMKQ-PVGFSRVKLTNK-ATG-N-AQ--QI Ciona-intestinalis_ENSCINT00000017704.3_NONE SRWMVAGKADP-ELPKRMYIHPDSPATGEQWMNRPGVSFHKLKLTNN-IADPH-GH---T Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri GEWMVAGKGEL-HSPQRMFLHPDSPSPGRKWMND-IISFYKIKLSNS-VNGRSTDK---I Ciona-intestinalis_ENSCINT00000034896.1_NONE GEWVVAGRGEP-QVPQRFYLHPNSPCSGQQWMKE-IISFHKVKLTNS-CGNSADGK---F Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript GEWIPGGKPEP-HVSSCAYIHPDSPNFGSHWMKQ-PVGFSRVKLTNK-ATG-N-PQ--QI Botryllus-schlosseri_botctg005874g48703_NONE GRWIVAGRADL-PYHQQVFVHPLSSSTGEDIMNK-IVSFHKVKLTNSPLKLQN-GK---F Botryllus-schlosseri_botctg007226g53212_NONE SRWMVAGKADP-ELPKRMYIHPDSPATGEQWMNRPGVSFHKLKLTNN-IADPH-GH---T Botryllus-schlosseri_botctg002459g63408_NONE GDWIPGGKPEP-HTPPCVYVHPDSPNFGAHWMKQ-PVSFNKVKLTNK-GNG-G-SQ--QI Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin GKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQ-EISFGKLKLTNNKGANNNNAQ--MI Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 GKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQ-EISFGKLKLTNNKGASNNNGQ--MV Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 NKWSVTGKAEP-AMPGRLYVHPDSPATGAHWMRQ-LVSFQKLKLTNN-HLDPF-GH---I Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 GEWVPAGKPEP-PNHSCVYIHPDSPNFGAHWMKA-AISFSKVKLTNK-LNG-S-G---QI Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra GEWVPGGKPEP-QAPSCVYIHPDSPNFGAHWMKA-PVSFSKVKLTNK-LNG-G-G---QI Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti GKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQ-EVSFGKLKLTNNKGASNNVTQ--MI Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin GKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQ-EISFGKLKLTNNKGANNNNTQ--MI Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc GKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQ-EISFGKLKLTNNKGASNNNGQ--MV Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio NKWSVTGKAEP-AMPGRLYVHPDSPATGAHWMRQ-LVSFQKLKLTNN-HLDPF-GH---I Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti GEWVPAGKPEV-SSHSCVYIHPDSPNFGAHWMKA-PISFSKVKLTNK-LNG-G-G---QI Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio GEWVPGGKPEP-QAPSCVYIHPDSPNFGAHWMKA-PVSFSKVKLTNK-LNG-G-G---QI 850 860 870 880 890 900 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 VLNSMHKYQPRIHVIEVGS-------------------HGPNE------------QKSLQ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ILNSMHKYQPRFHLVRAND----------------------------ILKLPY--SAFR- Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ILNSMHKYQPRVHVVQAND----------------------------IFTMRW--NSFN- Crassostrea-gigas_EKC28765_Brachyury-protein MLNSLHKYEPRLHLVKVG---------------------ANSQ------------KKRIS Pinctada-fucata_pfu26-120078t1_NONE ILNSMHKYQPRIHIVKKKEG-----------------SGGGGAGG-SITSLDA--EEFK- Pinctada-fucata_pfu930-101250t1_NONE ILNSMHKYQPRFHLVRAND----------------------------ILKLPY--SAFR- Pinctada-fucata_pfu5110-102705t1_NONE VLNSMHKYQPRIHVIEVGS-------------------CGPND------------QKNLQ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ILNSMHKYQPRIHIVQRQK-------------------ANPLD----PNKVVM-SEEKHC Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa IVNSMHKYRPRVHIIEQDD---------------------------------S--QKRH- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ILNSMHKYQPRLHVVRCAD----------------------------RHNLMY--STFR- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN VLASMHKYQPRLHVIRTAD----------------------------LAQIPW--APQQ- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN VLASMHKYQPRLHIIRSSE----------------------------LTQLPW--APQQ- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ILNSMHKYQPRFHLVRAND----------------------------ILKLPY--STFR- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI MLNSLHKYEPRVHLVRVGS------------------E-----------------QRHVV Saccoglossus-kowalevskii_Sakowv30002752_NONE VLNSMHKYQPRIHVIEVSP-------------------NRPPD------------QRTLQ Saccoglossus-kowalevskii_Sakowv30012255_NONE VLNSMHKYQPRFHIVQAND----------------------------VFSLRW--NSFS- Saccoglossus-kowalevskii_Sakowv30011577_NONE MLHSLHKYEPRVHIIKVG---------------------GNEK------------QRMVS Ptychodera-flava_PF12118-t1_NONE VLNSMHKYQPRIHVIEVSP-------------------NRPPD------------QRTLQ Ptychodera-flava_PF10086-t1_NONE ILNSMHKYQPRFHIVKAND----------------------------ILKLPW--SQFR- Ptychodera-flava_PF18712-t1_NONE VLNSMHKYQPRFHIVQAND----------------------------VFSLRW--NSFS- Ptychodera-flava_PF18670-t1_NONE MLHSLHKYEPRVHIIKVG---------------------GNEK------------QRMIS Acanthaster-planci_oki84-25_NONE ILNSMHRYQPRFHVVHVSG------------------RKDFDDAP----------ERDFK Acanthaster-planci_oki58-6_NONE VLHSMHKYTPCIIISKLRRWPANVRGIGAPCSDPNLPTDGSVTKHRELASLPP-VGGRPA Acanthaster-planci_oki169-35_NONE ILNSMHRYQPRVHIARKADA-----------------HAGAMA-P-SLTSLSS--SELR- Acanthaster-planci_oki20-22_NONE VINSMHMYQPRIHVLDLTG------------------------------------ARVLQ Acanthaster-planci_oki15-190_NONE MLNSLHKYEPRIHVIRVG---------------------GPEK------------QRLIR Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ILNSMHQYQPRIHVLELSE------------------------------------SRSIQ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ILNSMHKYQPRFHIVKAND----------------------------ILKLPW--SQFR- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte MLNSLHKYEPRIHIIRVG---------------------GREK------------QRLVG Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ILNSMHKYQPRLHIVQAND----------------------------VYSLRW--NSFS- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like VLNSMHKYQPRLHIIEVTN-------------------RGGGG------------ERVLQ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform MLNSLHKYEPRIHIVKVG---------------------GPDN------------QRTLS Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform MLNSLHKYEPRLHIIKVG---------------------GPDN------------QRMIS Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ILNSMHKYQPRLHIVQAND----------------------------VYSLRW--NSFS- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo VLNSMHKYQPRLHIIEVSN-------------------RAGGG------------ERVLQ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo MLNSLHKYEPRIHIVKVG---------------------GPDN------------QRTLS Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo MLNSLHKYEPRLHIIKVG---------------------GPDN------------QRMVS Oikopleura-dioica_GSOIDT00014261001_NONE ILHSMHKYQPRVHVVEIPE--------------------GVDV-----------CRYPTS Oikopleura-dioica_GSOIDT00006159001_NONE VLNSMHKYRPRVHIIKANS----------------------------LAAISS--SPFS- Oikopleura-dioica_GSOIDT00004289001_NONE ILNSMHKYQPRFHVARCDD----------------------------LSKLSY-CTSFSK Oikopleura-dioica_GSOIDT00007455001_NONE ILNSMHKYQPRFHIVRCND----------------------------LSRIHM--TTFR- Oikopleura-dioica_GSOIDT00000279001_NONE MLHSLHKYEPRVHIIKIGG------------------TAGA--------------QEFVK Ciona-savignyi_ENSCSAVT00000016577.1_NONE ILNSMHKYQPRFHVVRCGD----------------------------LAKLPY--CAFR- Ciona-savignyi_ENSCSAVT00000020041.1_NONE VLNSMHRYQPRVHIVRTDD----------------------------VNTLHL--QPMS- Ciona-savignyi_ENSCSAVT00000003855.1_NONE MLNSLHKYEPRIHIMKVG---------------------GAES------------QQIVA Ciona-intestinalis_ENSCINT00000017704.3_NONE ILNSMHKYQPRFHVVRCGD----------------------------LAKLPY--CAFR- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri VLNSMHRYQPRIHIVRTDD----------------------------VNTLHL--QPMS- Ciona-intestinalis_ENSCINT00000034896.1_NONE LIHSMHRYQPRIHIVRTDD----------------------------VNTLHL--QPMS- Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript MLNSLHKYEPRIHIMRVG---------------------GAES------------QQVVA Botryllus-schlosseri_botctg005874g48703_NONE LLHSLHRYQLRVYIARCDS-----------------------------------LEDIF- Botryllus-schlosseri_botctg007226g53212_NONE ILNSMHKYQPRFHVVRCGD----------------------------LSKLPY--CHFR- Botryllus-schlosseri_botctg002459g63408_NONE MLNSLHKYEPRIQVVKVGV------------------DSSS--------------QRTIA Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin VLQSLHKYQPRLHIVEVTE-------------------DGVEDLN---------DSSKTQ Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 VLQSLHKYQPRLHVVEVNE-------------------DGTEDTN---------QPGRVQ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ILNSMHKYQPRLHIVKADE----------------------------NNGFGSKNTAFC- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 MLNSLHKYEPQVHIVRVG---------------------GP--------------HRMVM Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra MLNSLHKYEPRIHIVRVG---------------------GP--------------QRMIT Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti VLQSLHKYQPRLHIVEVND-------------------GEPEAAC---------NASNTH Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin VLQSLHKYQPRLHIVEVTE-------------------DGVEDLN---------EPSKTQ Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc VLQSLHKYQPRLHVVEVNE-------------------DGTEDTS---------QPGRVQ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ILNSMHKYQPRLHIVKADE----------------------------NNGFGSKNTAFC- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti MLNSLHKYEPQVHIVRVG---------------------SA--------------HRMVT Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio MLNSLHKYEPRIHIVRVG---------------------GP--------------QRMIT 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 THAFPETQFIAVTAYQNTDVS--------------------------------------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 TYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDSGSGKREK-KRLLMSSI----HQS Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 TYAFEETVFIAVTAYQNEQITQLKIDNNPFAKGFRDNGMGRRDH-RLSM--------KRP Crassostrea-gigas_EKC28765_Brachyury-protein SFSFPETQFIAVTAYQNEEITALKIKHNPFAKAFLDAKE-RPDG---------------- Pinctada-fucata_pfu26-120078t1_NONE TFIFPESVFIAVTAYQNQLITKLKIDSNPFAKGFRDST--------------------RL Pinctada-fucata_pfu930-101250t1_NONE TYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDSGSGKREK-KRLLLSSS----QQS Pinctada-fucata_pfu5110-102705t1_NONE THAFPETQFIAVTAYQNTDITQLKIDNNPFAKGFRDNYDG-RNI-DNSTPPNQ-GYIPFP Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 TYTFPETQFMAVTAYQNQLITKLKIEKNPFAKGFRDPTG------R-------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa TFSFEETEFIAVTAYQNHRITSLKIESNPFAKGFR------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 TFVFRETEFIAVTAYQNEKVTELKIENNPFAKGFRDAGAGKREK-KRQLHRM-------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN AFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKR-------------KMS Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN AFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKR-------------KLN Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 TYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREK-KQALMSN------RG Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI TYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKE-RPDT---------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE THSFPETQFFAVTAYQNTDITQLKIDHNPFAKGFRDNYDCFNRS---------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE TYAFQETQFIAVTAYQNEKITQLKIDNNPFAKGFRDNGLSRRLD-RGI---------KRS Saccoglossus-kowalevskii_Sakowv30011577_NONE THTFKDTRFIAVTAYQNEEITALKIKHNPFAKAFLDAKE-RCDS---------------- Ptychodera-flava_PF12118-t1_NONE THSFPETQFFAVTAYQNTDITQLKIDHNPFAKGFRDNYDSFNRT---------------- Ptychodera-flava_PF10086-t1_NONE TYVFKETEFIAVTAYQNEKITQLKIDHNPFAKGFRDNGAGKREK-RKL----------QS Ptychodera-flava_PF18712-t1_NONE TYAFQETQFIAVTAYQNEKITQLKIDNNPFAKGFRDNGLSRRLD-RGI---------KRP Ptychodera-flava_PF18670-t1_NONE THTFKETRFIAVTAYQNEEITALKIKHNPFAKAFLDAKE-RYDG---------------- Acanthaster-planci_oki84-25_NONE TFIFQETQFTAVTAYQNHRITQLKIASNPFAKGFRECDP---------------DDCIRA Acanthaster-planci_oki58-6_NONE RFEFRETSFIAVTAYHSEQITQLKIQNNPFAKAFRDADVTAILQ---------------- Acanthaster-planci_oki169-35_NONE SYEFAETAFTAVTAYQNQLITRLKIDSNPFAKGFRDSS--------------------RL Acanthaster-planci_oki20-22_NONE THSFPETQFIGVTAYQNTDITQLKIDHNPFAKGFRDNYDSFATR-------------ERL Acanthaster-planci_oki15-190_NONE SFSFPETQFIAVTAYQNEDITQLKIKFNPFAKAFLDIKE-KGEH---------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte THSFPETQFFGVTAYQNTDVTQLKIDYNPFAKGFRDNYDNLSPR---------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara TFVFVETVFIGVTAYQNEKITQLKIDYNPFAKGFRDTGAGKREK-RKYIGAT------GT Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte SYSFTETRFIAVTAYQNEDITQLKIKYNPFAKAFLDIKDNRNDG---------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like TFAFPETSFIAVTAYQNEKITQLKIDNNPFAKGFRDNG-GNR-RERAILGTK------RS Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like SHSFPETQFIAVTAYQNTDITQLKIDYNPFAKGFRDNYDGPTNI-R----PN--GYDGRP Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform THTFAETQFIAVTAYQNEELTALKIKHNPFAKAFLDAKE-RNDT---------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform THTFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKE-RSDG---------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like TFAFPETSFIAVTAYQNEKITQLKIDNNPFAKGFRDNG-GNRSRERAIVSTK------RS Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo SHSFPETQFIAVTAYQNTDITQLKIDYNPFAKGFRDNYDGPTNI-R----PN--GFDGRS Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo THTFAETQFIAVTAYQNEELTALKIKHNPFAKAFLDAKE-RNDT---------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo THTFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKE-RSDG---------------- Oikopleura-dioica_GSOIDT00014261001_NONE TFTFREAQFITVTAYQNQAITKLKINRNPFAKGFRNNG--RNAK---------------- Oikopleura-dioica_GSOIDT00006159001_NONE TFDFQNTSFIAVTAYQNNAVTKLKIAHNPFAKGFRERAPAK----------------KRV Oikopleura-dioica_GSOIDT00004289001_NONE TFVFPEMSFIAVTAYQNERITQLKIDHNPFAKGFRDNGHARKDK-------------KRS Oikopleura-dioica_GSOIDT00007455001_NONE TYIFKETQFIAVTAYQNEKITQLKIDHNPFAKGFRDAGAGKREK-RX------------- Oikopleura-dioica_GSOIDT00000279001_NONE TQPFPMTRFIAVTAYQNEEITSLKIRHNPFAKAFLDAEQ-RKQN---------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE TYVFKEMQFIAVTAYQNEKITQLKIDHNPFAKGFRDSGSGKREKRRQHFHLQ------QQ Ciona-savignyi_ENSCSAVT00000020041.1_NONE TFAFPQTVFITVTAYQNSQVTKLKINNNPFAKGFRDNG-GRTNK------NK------KP Ciona-savignyi_ENSCSAVT00000003855.1_NONE THSFTETRFIAVTAYQNEDVTSLKIKYNPFAKAFLDAKESRTET---------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE TYVFKEMQFIAVTAYQNEKITQLKIDHNPFAKGFRDSGSGKREK-RQHFHLQ------QQ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri TFAFPQTVFVTVTAYQNGQVTKLKINNNPFAKGFRDNG-GRSNK------TN------RS Ciona-intestinalis_ENSCINT00000034896.1_NONE TFAFPQTAFVTVTAYQNGQITKLKIANNPFARGFREDG-AKTK----------------- Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript SHSFQETRFIAVTAYQNEDVTSLKIKYNPFAKAFLDAKE-RSGS---------------- Botryllus-schlosseri_botctg005874g48703_NONE SFSFVETNFITVTAYQNSQLSQLKIATNPYSKGFLPGGTRRRVK------------QSRK Botryllus-schlosseri_botctg007226g53212_NONE TYVFKEMQFIAVTAYQNEKITQLKIDHNPFAKGFRDSGSGKREKRRQHFHLD------RP Botryllus-schlosseri_botctg002459g63408_NONE TFSFPETKFIAVTAYQNEEV---------------------------------------- Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin TFIFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTA---------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 TFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTG---------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 THVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHR-MSRMQSKEYPVVPRS Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 NCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKE-RNHP---------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra SHSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKE-RNDH---------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti IFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTS---------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin TFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTA---------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc TFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTG---------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio THVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHR-MSRMQSKEYPVVPRS Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti NCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKE-RNHL---------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio SHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKE-RSDH---------------- 970 980 990 1000 1010 1020 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ST-AYTDEGSRVDDPQSDEDD--EICVDE------------TDDVTEDTVSILSRL---- Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 AG---------------------EDSISEIGKDNFAKKIKMEDEGHERKISSRIKSED-- Crassostrea-gigas_EKC28765_Brachyury-protein --------------------------------------RDLGDDGLDN-QQRSLSHLAST Pinctada-fucata_pfu26-120078t1_NONE TE--------------------------------------FES----------------- Pinctada-fucata_pfu930-101250t1_NONE SSETHADDASHADDTHSDDDDDAEICVDE------------TDDAMETPIPISTQL---- Pinctada-fucata_pfu5110-102705t1_NONE SY---------------------------------------------------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -----------------------------------------NGDATQSPPGKTASL---- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN SSPTGEDQDQSPSLSHS----------------------QSQSESDMSPTKGGGETAG-- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN SS------------GNS----------------------TLESEDD-------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 SD---------------------------------------SDKLNPTHVSSSRAPLH-- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -------------------------------------------------LYPHDTHYG-- Saccoglossus-kowalevskii_Sakowv30002752_NONE -------------------------------------MERFTPSPTAL---GSRSNPT-- Saccoglossus-kowalevskii_Sakowv30012255_NONE SS-----------------------CLET-----------FD-ESTDANKKVSSSTAG-- Saccoglossus-kowalevskii_Sakowv30011577_NONE --------------------------------------RDLFAEAHVHDMQQQCSQLGG- Ptychodera-flava_PF12118-t1_NONE -------------------------------------IDRFTPSPTPTPVHSSHYNASS- Ptychodera-flava_PF10086-t1_NONE ANLEASEHRTQPELSNS--------CTSQ------------SKEAEQTEVSTSSTK---- Ptychodera-flava_PF18712-t1_NONE SG-----------------------CIET-----------FDHENPDSNKKVSSSTAG-- Ptychodera-flava_PF18670-t1_NONE --------------------------------------RDYISEAHAHDVQQQCSQLGG- Acanthaster-planci_oki84-25_NONE SS---------------------------------------------------------- Acanthaster-planci_oki58-6_NONE -------------------------------------GAFMLSEPNEL------------ Acanthaster-planci_oki169-35_NONE SD--------------------------------------FERERVET------------ Acanthaster-planci_oki20-22_NONE SY-----------------------------------VASLQEQRNRMKPGSTSSATV-- Acanthaster-planci_oki15-190_NONE --------------------------------------D--LDECHDH-QQPRYPQLGS- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte -----------------------DISILSNA----------------------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara YEIDHGDD------------------IPS------------DQEAETAEVSTTSNDRHEE Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte --------------------------------------HDLFDDVHDF-QGSKYPQFGG- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like AEAAGDRSDSGVSNKRP--------CNGG------------EAER-NRPPSRDCSVVGEE Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ASIE-------------------------------------------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform --------------------------------------KSGHDDLTD--QQPQFSQLGG- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform --------------------------------------KDGLEDLQD---QPQYSQLGG- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ADAAGEPGDS-VSNKRP--------CTGE------------QTERNNRPPSCDCSGVGEE Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo AGME-------------------------------------------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo --------------------------------------KSGHDDLTD--QQPQFSQLGG- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo --------------------------------------KDGMEDLQD---QPQYSQLGG- Oikopleura-dioica_GSOIDT00014261001_NONE -------------------------------------VHNAYEQSGEPVPGSYAAHVA-- Oikopleura-dioica_GSOIDT00006159001_NONE SS---------------------------------------------------------- Oikopleura-dioica_GSOIDT00004289001_NONE AS---------------------IKCAQH------------NSKKIKLDSSSSTNDEDAE Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE --------------------------------------D--------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE LVGSHKETSSNPHRH-----------LYS------------NSDRTDCNVSTDDDT---- Ciona-savignyi_ENSCSAVT00000020041.1_NONE SS----------DNQPD--------TTYE---------------RNLGKSSRESGAKDNE Ciona-savignyi_ENSCSAVT00000003855.1_NONE --------------------------------------ETYYKDTANAGTSQTYARVSS- Ciona-intestinalis_ENSCINT00000017704.3_NONE MVGNHKEAASNPTRQTS---------VYS------------NSERSECNVSTDDDT---- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri SSGRGSIGLVQPSNEEE--------NTKEP---------HSEETRNSQTRKRKANKLEYA Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript --------------------------------------ENYFKDSTKAGSSQNYSRANT- Botryllus-schlosseri_botctg005874g48703_NONE HE------------------EC-------------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE MMGKRLSDDSS--------------KIAS------------DGLSDDCQVPRSDTRRFSA Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---------------------S-------------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ---------------------C-------------------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 TV---------------------RQKVSS----------NHSPFSGETRVLSTSSNLGSQ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 --------------------------------------KDAPEAASEG-QHMTYSH---- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra --------------------------------------KDMMEEAGDN-QQSGYSQLGS- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------------------V-------------------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---------------------S-------------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ---------------------C-------------------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio TV---------------------RQKVAS----------NHSPFSSESRALSTSSNLGSQ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti --------------------------------------RDVPEAISES-QHVTYSHLGG- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio --------------------------------------KEMMEEPGDS-QQPGYSQSGG- 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ----------------------------------------------IQD----------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ----HSGKK--------------------------------------------------- Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ---------------------------ENDSIPP--------------TPES-HHADG-- Crassostrea-gigas_EKC28765_Brachyury-protein ---------------WYIPP-------GGHALVPP--------------PAH-QFPNALN Pinctada-fucata_pfu26-120078t1_NONE -------------------------ALEKQGMLPH------------------------- Pinctada-fucata_pfu930-101250t1_NONE ----QSDSKDTVKTEAAE---VPAKESTDTSIKPNDDVPEVTDHMPKSFPPV-VKVSAH- Pinctada-fucata_pfu5110-102705t1_NONE --------------------GQHPYQNGH---------------YGSQDPML-RANQGI- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------SPDE-------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa -------------------------ECEVQGIEMNSV----------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 --PTHSPHP------------------SESNSE--DD-----------EPTL-KKCK--- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ---------------------------GTSSIG-------DSD-----GPQI-KRLR--- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ----------------------------GSSVS-------SCD-----SPQA-KRQR--- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 --LGHAGRPPHLHPHAAL---LDNQQDDDDKLL---DVV---------GPPQ-SPLL--- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ---------------WLIPPPTHYTAAAAAVAAPPPLSIAQSHGLVASCPSV-SSAESVG Saccoglossus-kowalevskii_Sakowv30002752_NONE --------------------------------GPYP--------VGPALPIG-SSFNSIH Saccoglossus-kowalevskii_Sakowv30012255_NONE ---------------------------EGNNVF-----------MTST---K-KEDKD-- Saccoglossus-kowalevskii_Sakowv30011577_NONE ---------------WFL-P-------GTSALCPAP------------DPR--QFS-SIG Ptychodera-flava_PF12118-t1_NONE ---------------------------GQTRQSPYP--------VGMPIP-A-ATFNAMQ Ptychodera-flava_PF10086-t1_NONE ----QNAQE------------------TDDSVR---------------LPPV-V------ Ptychodera-flava_PF18712-t1_NONE ---------------------------ETTTAF-----------LTPPGPGK-KEEKE-- Ptychodera-flava_PF18670-t1_NONE ---------------WFL-Q-------GASPLCPAP------------DPR--QFS-ALG Acanthaster-planci_oki84-25_NONE ---------------GLV---NTHQGSSIIEILPHSN-----------GPRT-------- Acanthaster-planci_oki58-6_NONE ----------HF-------P-----SMSSGGLMPSMHPGCH------TLPMDWQTTSSPC Acanthaster-planci_oki169-35_NONE -----------------L---IQEHTYARSPIRPHEG----------------------- Acanthaster-planci_oki20-22_NONE -------------------P------SDTSGLSRSQ------------NPVQFADSRHER Acanthaster-planci_oki15-190_NONE ---------------WFL-P-------SAGTLCPP-------------SPHH-QFPPSLG Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte -------------------P-------RSKNVTVSRNSC--------PAPVV-------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara RERGHSSHE-------------LARLASEGRLN---------------GPGL-NKCK--- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ---------------WFL-P-------GSGAFGP--------------SPH--QFAPSIG Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like SEVPRGPSQ-------------YNPPAQSDDLNPCGN------------PLT-IVTD--- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like -------------------PGMHPSLGAPLPLMPP--------IYPVGPPIP-THSRGIP Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ---------------WFL-P-------GTGPICPPP------------NPH--QFAPSLG Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ---------------WFL-P-------GTGPICPPP------------NPH--QFAPSLG Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like SDVPRGPAQ-------------YNPPAQADDLNPCGN------------PLT-IVTD--- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo -------------------PGMHPSLGGPLPLMPP--------IYPVGPPMP-AHNRGIH Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ---------------WFL-P-------GTGPICPPP------------NPH--QFAPSLG Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ---------------WFL-P-------GTGPICPPP------------NPH--QFAPSLG Oikopleura-dioica_GSOIDT00014261001_NONE ---------------WRE---RMGKQGGATASSPHP------------PPPP-------- Oikopleura-dioica_GSOIDT00006159001_NONE ----------QL------------------------------------SPPT-QKR---- Oikopleura-dioica_GSOIDT00004289001_NONE ---------------EIV---VDVENVEDSAIE-------I-------RPAE-TIEKH-- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE -----------------L-P------------------I---------STSA-NYSNSNG Ciona-savignyi_ENSCSAVT00000016577.1_NONE --RANNSGS------------------STSSIT---------------SPIR-TEKR--- Ciona-savignyi_ENSCSAVT00000020041.1_NONE GSDQHNSKH-------------LKLDSDTFNFTMYPNID---------VPKS-VVSQ--- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ---------------W--------------------------------TPGI-NQANGDN Ciona-intestinalis_ENSCINT00000017704.3_NONE --RPNNSGG------------------STSSVT---------------SPTR-LEKR--- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri IESEHKLMH-------------YSYQSESNT-----NKT---------VPLD-------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ---------------W--------------------------------TA---NQSN--- Botryllus-schlosseri_botctg005874g48703_NONE -----------------------------------------------DLPGP-KRSRTEC Botryllus-schlosseri_botctg007226g53212_NONE SPESRHTHS-------------QSQDARTNTRKISGEQK-----QPLPLPGA-VQTQEV- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---------------------------ENDRLTPSPT----------DSPRSHQIVPGAR Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ---------------------------DMDRLTPSPN----------DSPRS-QIVPGAR Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 YQCENGVSS------------------TSQDLLPPTN----------PYPIS-QEHSQ-- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ---------------WLI-P-------GTGALCPPA------------NPHS-QFGAPLS Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------------------------DTS--IPSP-----------PGPNC-QFLGGDH Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---------------------------ENDRLTPSPT----------DSPRSHQIVPGGR Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ---------------------------DMDRLTPSPN----------DSPRS-QIVPGAR Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio YQCENGVSG------------------PSQDLLPPPN----------PYPLP-QEHSQ-- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ---------------WIF-S-------NPDGVCTAG------------NSNY-QYAAPLP Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ---------------WLL-P-------GTSTLCPPA------------NPHP-QFGGALS 1090 1100 1110 1120 1130 1140 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein LS---SPH----C----------------------------------------------- Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE PP---SKHTVEQMLATSPPKKDTEPKILIPSASYSVERNLTSSIDNESSQGVPRVKSPVS Pinctada-fucata_pfu5110-102705t1_NONE -PY-------GGTLEAKFSYQRNLSNTHV--------------------FQNGQ------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ----------GGMTGG-------------------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ----------SNGSACSLSSSLDDQSVPGA------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ----------QD---------FEQDST--------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -P---LSHSLQQMHAHQHS------------AALAAWFNHLAGAGAGASEHAAAAAANAS Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI PS---S---GGSC----------------------------------------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE NDQATAKEQIQQQFDNDDSKDKITGEL--------------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ---------LGSSL-SSDSTSRGNRTLPIN--------------------TSSETNAIPS Saccoglossus-kowalevskii_Sakowv30011577_NONE LHG--S---APGC----------------------------------------------- Ptychodera-flava_PF12118-t1_NONE NGTATS----QASMIGEVTKSK-TGDIV-------------------------------- Ptychodera-flava_PF10086-t1_NONE -P---SPR--EYVSAEANSTTRTEEEI-------DVESN-----DKENDTAANELKSEIA Ptychodera-flava_PF18712-t1_NONE ---------INNSLNTSTSSESSNQSLTID--------------------AGDHNSTSPI Ptychodera-flava_PF18670-t1_NONE LH---S---APGC----------------------------------------------- Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE RNQ--------------------------------------------------------- Acanthaster-planci_oki169-35_NONE ----------GTLNGTDGSAR----------YGLSC------------------------ Acanthaster-planci_oki20-22_NONE RP---------------------------------------------------------- Acanthaster-planci_oki15-190_NONE MP---SP-VSHSCA---------------------------------------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte --------------------------------------------NA-------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara -P--------SDMKGGPHGSSSSKDDVEM---------------------------RDVS Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte LP---S---HAGC----------------------------------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like -------------DITTDFAKERSPGLPHA--------------------LGGQGSAQLP Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like PPYDMRSHSSGESSSSPDSPEMQTKDLGSKDTASDVP----------GSTQNGQT----- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform LP---S----HGC----------------------------------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform LP---S----HGC----------------------------------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -------------DIATDFAKERSPGVPHA--------------------LGGQGSAALP Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo LPYDMRSHSSGGSSSSPGSPEMQPKDLELKETASDLP----------GSAQNGQS----- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo LP---S----HGC----------------------------------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo LP---S----HGC----------------------------------------------- Oikopleura-dioica_GSOIDT00014261001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE -------------NTSSSSSSSSNSAESHH--------------------------QPVE Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE RSA--A---------------QN------------------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE -G---VD---SACAVGDNSTKISRNSIADD--------------------------EHLS Ciona-savignyi_ENSCSAVT00000020041.1_NONE -P---M---LGDYRLNVSAASEANTALPFY--------------------PYPQHMYHYP Ciona-savignyi_ENSCSAVT00000003855.1_NONE LP---S---VYHCDP----ATRNDFGVNPMFAPTNCPSPYQP------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE -A---TDY--SETIIGESSSKKSRTSITED--------------------------DHMS Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -------------RLNPAAVVGPTTGYPFY--------------------SYPQAIHHTP Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript -P---T---FNQC--------QYESGIPPFHYPI----PNQP------------------ Botryllus-schlosseri_botctg005874g48703_NONE TPI--------------------------------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE SG---KSGFLSDCSSNSPERRRTPEVTSSS-------------------RDGGQI----- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin YSV--Q-PFFQEQFVNNLPPTRFYNG---------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 YAM--AGSFLQDQFVSNYAKSRFHPGAGAG------------------------------ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -----SPQAPHGC----------------------------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra LS---P---AHSC----------------------------------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti YS-----PLLPNQYP---VPSRFYPDL--------------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin YGV--Q-SFFPEPFVNTLPQARYYNG---------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc YAM--AGSFLQDQFVSNYAKARFHPGAGAG------------------------------ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti LP---APHTHHGC----------------------------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio LP---S---THSC----------------------------------------------- 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 --------------LDGDLQPLHPKTS------------------PVN------------ Crassostrea-gigas_EKC28765_Brachyury-protein -------------------DRLS-LRN--------------------------------- Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE DCDNDRR---RSR--------SPSPRSMGS--------------RS-------------- Pinctada-fucata_pfu5110-102705t1_NONE ---------------------------DQENVKM------------YYD----------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ---------------------------------ME-------R-SPGDMMLSNF------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ----------------------SSLALGSP--------------PPHL------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ---------------------------GSV--------------SPAY------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 AEDALRR---RLQ----AD--ADVERDGSD--------------SSCSESVGGS------ Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -------------------DRYGRSLSSRSV-------------APT------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE -----------------DPIKFENFPPNTI--------------TPHNYDMSQIQQQMRL Saccoglossus-kowalevskii_Sakowv30012255_NONE NKKMQVPHTDRL--VCTTADNTSKEVDDPS--------------SP--ISKSST------ Saccoglossus-kowalevskii_Sakowv30011577_NONE -------------------ERYNSLRSHRS--------------APY------------- Ptychodera-flava_PF12118-t1_NONE ----------------QDAIKYENFPPNTV--------------TPHSYDMNQIQQQLRV Ptychodera-flava_PF10086-t1_NONE -AERARE---RERGLSAADDTSDEERDVEE--------------ND-------------- Ptychodera-flava_PF18712-t1_NONE NKDKTQPNGGRLSHLSTQLSPTAKDDDDPC--------------SPNSIAKSST------ Ptychodera-flava_PF18670-t1_NONE -------------------ERYSGLRSHRS--------------APY------------- Acanthaster-planci_oki84-25_NONE ----------RNH------------------------------HRPSSLQIVGI------ Acanthaster-planci_oki58-6_NONE --------------LDPNMAGYGTSLDDALYWRGGHVRVPEFSDSPWSFDNVAALH---- Acanthaster-planci_oki169-35_NONE ------------------------------------------------------------ Acanthaster-planci_oki20-22_NONE --------------------------------------------LPVSLLRGSEL----- Acanthaster-planci_oki15-190_NONE ------------------VERYSSLRTHRS--------------TPY------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte --------------ANIAMGQFPAMISHQSGHYQ----------HPYHHHAHHA------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara CKDHERRMDGKHR-LSQDDSSIDKKTDHNE--------------RSDSRKSDG------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte -------------------DRYGGLRGHRT--------------SPY------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like TRDQASLGS-----CQGDDMRCQTRTACAQ--------------DPRD------------ Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like --------------NATPEKQVSPARVNNSNLLLT-------TTAPYTI----------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -------------------DRYSTLRNHRS--------------APY------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -------------------DRYSTLRNHRS--------------APY------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like TRDQAALGS-----CQGEDMRCQTRTACAQ--------------DPRD------------ Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo --------------NATPEKQASPTRVNNSNLLLT-------TTAPYTV----------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -------------------DRYSTLRNHRS--------------APY------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -------------------DRYSTLRNHRS--------------APY------------- Oikopleura-dioica_GSOIDT00014261001_NONE --------------------------------------------APWS------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE IKEENSSSA-----CDSSTASSEGNSIESS--------------SP-------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE -------------------NRRKR-AENRT--------------QPYK------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE TDEKSKNEVFKQERLPSPIKKSPEPSNHRD--------------SPHS------------ Ciona-savignyi_ENSCSAVT00000020041.1_NONE T--------------------VHTNTV------------------PHY------------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE ----------------YARERSSS-RSQRS--------------Q-Y------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE NDEKSKNEVFRRETLTSPLKKTPEAASHRR--------------SPHS------------ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -------------------------TA------------------PHP------------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ---------------KTTRERRMS-RTQRS------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE --------------------------------------------RPQRKQNDAQ------ Botryllus-schlosseri_botctg007226g53212_NONE --------------LENKKTPLIPTKFDER--------------GPLRVSPRSP------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------------ERTVPQTNGLL--------------SPQQSEEVAS------ Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 --------------PGPGADRSVPHTNGLL--------------SPQQAEDPGA------ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 --------------IYHCTKRKDEECSTTE--------------HPYKKP---------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -------------------ERYSALRGHRA--------------APY------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -------------------ERYSPLRNHRS--------------APY------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------------------------------------------PGQAKDVV------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------------ERTVPQTNGLL--------------SPQQSEEVAN------ Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc --------------PGPGTDRSVPHTNGLL--------------SPQQAEDPGA------ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio --------------IYHCTKRKEEECSTTD--------------HPYKKP---------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -------------------EHYSGLRGHRQ--------------APY------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -------------------DRYPTLRSHRS--------------SPY------------- 1210 1220 1230 1240 1250 1260 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 -------------------GSTTGPLKATS------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein ----------------------------------AG-------FSRD--------V---- Pinctada-fucata_pfu26-120078t1_NONE ------------------------PH---------------------W------------ Pinctada-fucata_pfu930-101250t1_NONE ------------------------PENSRS------------------------------ Pinctada-fucata_pfu5110-102705t1_NONE -------------------NGFNSPYRQVP-------------VHN---------I---- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 -------------------------------------------YHSSA------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------PA-FQSV----------------F------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------PEPSQT------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -------------------HSHSHP----------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -------------------YGATHPV---------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ------------------TGGAFRPTSTGS------------------------------ Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ---------------------RTTPYSRPRVVSGS---------GSNG----SA------ Saccoglossus-kowalevskii_Sakowv30002752_NONE GYAAGAP-PRGRIGGNQLLLATTQPYACTASTVPTY-------TTSSA----NHYS---- Saccoglossus-kowalevskii_Sakowv30012255_NONE --------------------SITHPLHKNRH------------FGNQL----TS------ Saccoglossus-kowalevskii_Sakowv30011577_NONE ----------------------PSPYQKHSQTANS--------YAAE------------- Ptychodera-flava_PF12118-t1_NONE NYSR-----------SNLLLTTTQPYMASTSTYTTT-------TASQL----RSTR---- Ptychodera-flava_PF10086-t1_NONE ------------------------TSTNLS------------------------------ Ptychodera-flava_PF18712-t1_NONE --------------------SITHPLHKNRH------------FGNPM------------ Ptychodera-flava_PF18670-t1_NONE ----------------------PSPYQKHSQSANG--------YPSD------------- Acanthaster-planci_oki84-25_NONE --------------------SRSRPLTHRQQT---------NEQNSEAN---RGTT---- Acanthaster-planci_oki58-6_NONE ------P-------------SGTHPHDTDSSVRAINRRQGLLPYRSHPTMA--------- Acanthaster-planci_oki169-35_NONE -------------------GGAVMPHNFQECTDAGKGLL---SFAEQF------------ Acanthaster-planci_oki20-22_NONE --------SQ---------LTDSPPYGSSPSGHGVC-----SEMATSST-AHSSPE---- Acanthaster-planci_oki15-190_NONE ---------------------PPPPYEQKYSPTSA--------YATDA----SA------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte -------------------HYHPPPHHQHQQRPHLP----LPTFHHRP------------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ------------------------PSSRLS------------------------------ Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ---------------------PPPPYHQKYSAAGAG-------YGAEA----SAGL---- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like --------------------LLASPDTTD--------------Y-QQY------------ Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like --------------------ASGQPHYSMA-------------MHNRG----MPPQ---- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ----------------------PHPY-QRSSPPTN--------YGHD-----TA------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ----------------------PHPY-QRSSPPTN--------YGHD-----TA------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like --------------------LLASPDSAD--------------YHQQY------------ Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo -------------------NSSGQPHYSMAMT-----------MHSRG----MPPR---- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ----------------------PHPY-QRSSPPTN--------YGHD-----TA------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ----------------------PHPY-QRSSPPTN--------YGHD-----TA------ Oikopleura-dioica_GSOIDT00014261001_NONE ---------------------HPQPEITSHSQHAVSHTL----YHSPD------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------PRSLSPVC---------------------------- Oikopleura-dioica_GSOIDT00004289001_NONE --------------------AVPPPSPADD------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ---------------------RPVPVAKSEPISSID-------FGAQ------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE ---------------------PLKPRVKDS------------------------------ Ciona-savignyi_ENSCSAVT00000020041.1_NONE --------------------AAINPP-----------------FNYQL------------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE ---------------------NYHPYSHREAHHSMP-------YHQDL----STPIDVNA Ciona-intestinalis_ENSCINT00000017704.3_NONE ---------------------PIKPRVKDS------------------------------ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri --------------------LLHYPPPMRNL------------FSGQS------------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript -----------------------HPYKPSTTQ-----------IYQDF----Q------- Botryllus-schlosseri_botctg005874g48703_NONE -----------------MMNSASAPISNIGHYVENCDRHQLHQFNEVY------------ Botryllus-schlosseri_botctg007226g53212_NONE --------------------TLSPPSSVTS-----------------------S------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ------P-PQ-----RWFVTPVQQPSANKLDM--NS-------YETEY----SPSTLLPY Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ------PSPQ-----RWFVA----PANNRLDFAASA-------YDTATDFAGNAATLLSY Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 -------------------YMETSPAEEDPF------------YRSSY------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ----------------------PPSYMQRNHSPTVN-------FFES-----SS------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ----------------------PNPYTHRNNSPTA--------YTDN-----SS------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti --------PQ-----AYWLG---APRD-------HS-------YEAEF----RAVSMKPA Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ------P-PQ-----RWLVTPVQQPGTNKLDI--SS-------YESEY----TSSTLLPY Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ------PSPQ-----RWFVT----PANNRLDFAASA-------YDTATDFAGNAATLLSY Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio -------------------YMETSPSEEDSF------------YRSSY------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ----------------------PSAYMHRNHSPSVN-------LIES-----SS------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ----------------------PSPYAHRNNSPT---------YSDN-----SP------ 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 -------------PTQSATL------------QQT----HCQY----------------- Crassostrea-gigas_EKC28765_Brachyury-protein ---------TSNIPMLNIPD------------NWM---TPTNP----------------- Pinctada-fucata_pfu26-120078t1_NONE -------------PV--------------------------------------------- Pinctada-fucata_pfu930-101250t1_NONE -------------P---------------------------------------------- Pinctada-fucata_pfu5110-102705t1_NONE ---------NNNQPQIEGNN------------ELSRCKVKEEVV---------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa -------------PL--------------------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -------------PTTS------------------------------------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -----------H-PLQARSA--------------------------------SSVFMQH- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ----------AN-PM--------------------------------------SPYLRHH Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -------------PKEAVGA---------------------------------------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ---------GNASSTSPQPP------------SAPQTPTSLHST---------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------AGSSPNTTEHD------------AWVNTPPSNVSS-DSEV----------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ----------VNATDANITS------------CSRRTS-H-------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE -------------SMLSAHE------------NWPALPVSSH------------------ Ptychodera-flava_PF12118-t1_NONE ---------TSSSPNQEDPNS----------SSWISTPLSNSSS-DSGI----------- Ptychodera-flava_PF10086-t1_NONE -------------PKGACND---------------------------------------- Ptychodera-flava_PF18712-t1_NONE -------------PESNMAS------------CSRRSSTH-------------------- Ptychodera-flava_PF18670-t1_NONE -------------SMLSAHE------------NWSGLPVTSH------------------ Acanthaster-planci_oki84-25_NONE -------AASVSPPMTSEPS---------------------------------------- Acanthaster-planci_oki58-6_NONE ------FDAVGRTPMTSSGLSKRHRHSIGALQDALQVPKVNRTL--------SHPE---- Acanthaster-planci_oki169-35_NONE -------------PLTEE------------------------------------------ Acanthaster-planci_oki20-22_NONE ----SIIEQEGPLPILENPN---------------------------------------- Acanthaster-planci_oki15-190_NONE ----------STLPLLPTHE------------AWSPLGSSTH------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte -------------PQLAPAG------------SIGQTPAGCTTGPTGGNFRLPNPDETA- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara -------------P---------------------------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ---------SSSISLLAA-D------------SWSSLANSTS------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like -----------H-PGGYNSQ------------TAG------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ---------NGGLPQ---NG------------QMS-----ENSS---------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ----------ASLPMMPTHD------------NWSGLPVSTH------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ----------ASLPMMPTHD------------NWSGLPVSTH------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -----------H-PGGYSGQ------------AAG------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ---------NGGLPQ---NG------------QVS-----ENGN---------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ----------ASLPMMPTHD------------NWSGLPVSTH------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ----------ASLPMMPTHD------------NWSGLPVSTH------------------ Oikopleura-dioica_GSOIDT00014261001_NONE -------------PAISEVS-------------------------------------RY- Oikopleura-dioica_GSOIDT00006159001_NONE ----------NHVPIAHENS------------WSS------------------------- Oikopleura-dioica_GSOIDT00004289001_NONE ----------IK-P---------------------------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE -------------HMMPSFV------------QSMGIPIQA------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE -------------PMTSSST------------LSSPIPIHPGLTG-PGGY--PNAFMPH- Ciona-savignyi_ENSCSAVT00000020041.1_NONE -----------N-PTTYY------------------------------------------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE TPSHETLCYPTGYQVMTA-D------------QWPHTAIPHHDVAEQGT----------- Ciona-intestinalis_ENSCINT00000017704.3_NONE -------------PVTSSST------------LTSPIPIHPGLTG-LGGY--PNAFMPH- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -----------HEPTSTL------------------------------------------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ---------PTNYPALPN-D------------QW-QSSIEGHEL-DEGH----------- Botryllus-schlosseri_botctg005874g48703_NONE --------YANHIP---------------------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE ---------TITSP----------------------IPIHANSFASLGSY--PNPLMPH- Botryllus-schlosseri_botctg002459g63408_NONE -----------CINFL-------------------------------------------- Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin --------GIKSLPLQ-------------------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 AA-----AGVKALPLQAAGC---------------------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 -------------PQQQGLN------------TSYRTE---------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ----------NNLQVFSGHD------------SWT-LPSSPHA----------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ----------ACLPMLQSHD------------NWSSLGVPTHT----------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -----------FLPSA-------------------------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin --------GIKSLPLQ-------------------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc AA-----AGVKALPLQAAGC---------------------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio -------------PQQQGLG------------ASYRTE---------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ----------NNLQVFSGPD------------SWTSLSSTPHA----------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ----------ACLSMLQSHD------------NWSSLGMPAHP----------------- 1330 1340 1350 1360 1370 1380 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ---MSSAAKSY------------------------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein -------------------GML-----QSNTPAP-------------------------- Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE -------LYSR-PFSKDV-TSPPNVTVVQPSVSH-------------------------- Pinctada-fucata_pfu5110-102705t1_NONE LE-----------------SEIPVSVPGDSVGSNY------------------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------LQQAMF------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------FQQNMQ-SLLRPSL---------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN LS----------YGPSGA-AGLPPS----------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ---AAAAAAAG-LNPGGG-SYPSPNISVGPPIHP-------------------------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -------------------STGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVDAS Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------FEPQNKRQKISPI-NSANSSPIL------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ---LSNYPQQRGGDPINS-NYLSPTDS-LDEGPPL------------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------TSHP-------------------------- Ptychodera-flava_PF12118-t1_NONE ------------YEQPIKRQKLSPTADSPESLPSR------------------------- Ptychodera-flava_PF10086-t1_NONE ---VVMTTHDQ-VEDNDI-RSLTSSTDTRKDISEI------------------------- Ptychodera-flava_PF18712-t1_NONE ---VQNYAQQR-SEPLAS-NYLGSGDTAVNESSPM------------------------- Ptychodera-flava_PF18670-t1_NONE ------------------------------TTHT-------------------------- Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE IK----------FEPTASEPLALPTTNAAFEFSEFRQTL--------------------- Acanthaster-planci_oki169-35_NONE FS---------------------------------------------------------- Acanthaster-planci_oki20-22_NONE SS-----------------TQLESVFNTPPNQSPH------------------------- Acanthaster-planci_oki15-190_NONE -------------------------HTSNITTTS-------------------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte FKLVGN------VSHLSRPTFVPISPPDSSTSSPK------------------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara -------PSSR-LSPPSS-RLSPASLHLGSAGSSF------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ---------------------------AASSMPA-------------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like -------------DPTDN-TGVSLGYGTGPSFQEL------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like MA-----------------------QNGQSPGEE-------------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -------------------NMLSMSAMPHTTTST-------------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -------------------NMLSMSAMPHTTTST-------------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -------------DPTDT-TGVPLGYGTGPSFQEL------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo MA-----------------PNGHISQNGQSQGEE-------------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -------------------NMLSMSAMPHTTTST-------------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -------------------NMLSMSAMPHTTTST-------------------------- Oikopleura-dioica_GSOIDT00014261001_NONE FQ---------------------------------------------------------- Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE -------------------PVRTFSPDGSSAVLG-------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE LT--PAAAYQF-LHPSQM-NALSAAMSS-NAGNPY------------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE --------------P----------HYPHPGYEP-------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE FS----------LDQVSVEDMASLAFESATSSASL--------------TQSDFSTVD-- Ciona-intestinalis_ENSCINT00000017704.3_NONE LSGAAAAAYPF-LHPSQM-SALTAAMSAGGASNPY------------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri --------------PLSR-FGIPPTYEYHNLYNPF------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript FS----------LEPVSVDDVTALGFD--TPHQGF--------------ATNDLLSIEPS Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE FA-AALQSHPY-LHSNHL-SALSAAMSAHGN----------------------------- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------------TSHALGYYPDPTFPSM------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -------------------AGRPLGYYADPS----------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 -S-AQRQACMY--------------ASSAPPTDPV------------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -------------------NLLSVPHNKGATSPG-------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -------------------TMLPMSHSTGTATSS-------------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -------------------PGPTMSYYRGQEVLAP------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------------TSHALGYYPDPTFPAM------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc -------------------TGRPLGYYADPS----------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio -S-AQRQACMY--------------ASSAPPSEPV------------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -------------------SILSVPHTNGPINPG-------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -------------------SMLPVSHNASPPTSS-------------------------- 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------SQSCMASSNDQ------- Crassostrea-gigas_EKC28765_Brachyury-protein ----QSQY-SMWMG----------------------------------NHMGNIPTNQN- Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE -----PIFPYLYP----------YTTTSPNFPYS-----------------------V-- Pinctada-fucata_pfu5110-102705t1_NONE ------------------------------------------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ---------------------------------------VDLACTYFGRPHE-------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -----------------------------------------IAAAYFG------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -------SPHLLP----------YLYPHGLYPPPH-----------LGLLHN--PAAA-- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI PTASVFSYPSSWQSNGNYWNATSVPGPMPM---------NVCSGRNISSHNSPSPTNGS- Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------------------------------------------------ENSP----- Saccoglossus-kowalevskii_Sakowv30012255_NONE TSSQQ--------------------------------------QCSLGLAQNA------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ----SSQYPSMWQM----------------------------------G----TPVTSA- Ptychodera-flava_PF12118-t1_NONE ---------------------------------------------------ESSPIAKA- Ptychodera-flava_PF10086-t1_NONE EDM-RAEFRRCLP----------LTFFVAMFRF--------------------------- Ptychodera-flava_PF18712-t1_NONE TPSQNS------------------------------------TQCGMGVGHGA------- Ptychodera-flava_PF18670-t1_NONE ----APQYPAMWPV----------------------------------SN-ALTPVTTA- Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ------------------------------------------------SEGTYHPLRRV- Acanthaster-planci_oki169-35_NONE ------------------------------------RR---------------------- Acanthaster-planci_oki20-22_NONE ---------------------------------------------GGGEGSEKHPPAQKL Acanthaster-planci_oki15-190_NONE ----SHQYGSVWPP----------------------------------ATSSAVPPASI- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ----------------------PFPIPVPTSLAP------IIVQNSLCSTQQGQQTLQQ- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara SSLHGSHPPVVTPI---------YPTPQQLFLNPHALHGAV---PGLGAMQHMLPFSS-- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ----CSQYGSMWPS---------------------------------------TAATSGF Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like SVQTD-----------------------------------------LGT-ADM------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ----HAQYPNLWSV----------------------------------SNNNLTPTTHAQ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ----HAQYPNLWSV----------------------------------SNNNLTPTTHAQ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like SVQTD-----------------------------------------LGTAADM--ASA-- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ----HAQYPNLWSV----------------------------------SNNNLTPTTHAQ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ----HAQYPNLWSV----------------------------------SNNNLTPTTHAQ Oikopleura-dioica_GSOIDT00014261001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE -------------------------DPM------------------LPAHESGSPPLSM- Ciona-savignyi_ENSCSAVT00000016577.1_NONE SHLGS-FNPALLQ--------------------------AVVNAGGMSSLHR--PSSQT- Ciona-savignyi_ENSCSAVT00000020041.1_NONE HLQQ-------------------------------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE -SFDSSNFGAHWSY----------------------------------STN--------- Ciona-intestinalis_ENSCINT00000017704.3_NONE SHLGSAFNPALLQ--------------------------AVVNAGGMSSLHR--PSAQNP Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri HFQI-------------------------------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript YSLDYPQFTTTWSY----------------------------------PTN--------- Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------------------------------VFSGSGSINPALLHAAVA Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---------AGWGSRG-------------------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ----------GWGARS--------------------------------------PPQYC- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 PSLED-------------------------------IS---------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ----PSHYPCLWSV----------------------------------SNSAVSVTNPG- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -----SQYPNLWSV----------------------------------SNSTITPAPQS- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti --------GAGW------------------------------------------------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---------AGWGGRG-------------------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ----------GWGARS--------------------------------------PPQYC- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio PSLED-------------------------------IS---------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ----PSPYPCLWTI----------------------------------SNGAGGPSGPG- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -----SQYPSLWSV----------------------------------SNGAVTPGSQA- 1450 1460 1470 1480 1490 1500 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein -----------------------CAM-------------------PYLRSPNP------- Pinctada-fucata_pfu26-120078t1_NONE --------------------WRPIPS-------------------SLVGSASPY------ Pinctada-fucata_pfu930-101250t1_NONE GSMLLSG--------------SSSLS---------------------QGLQMPF--LPTS Pinctada-fucata_pfu5110-102705t1_NONE -----------------SDNEPQCPVV-----------------------CKEEAEETE- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 -------------QQCLSKTLQLNPSIM-----------------MLYQNVFPTG----- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa --------------------------------------------------IFPY------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -----------------SLSTSTTPT---------------------LSAHHPL------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -----YGG---------------------------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------GV---------------------------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 AAMSPAGL------NP-GLLFNAQLA---------------------LAAQHPA--LFGH Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -----------------PSYTTSSPS-------------------YTIHHLTPH----SH Saccoglossus-kowalevskii_Sakowv30002752_NONE ----------------RDEKETSEPMKE----------------KKPNLDQYPSA----- Saccoglossus-kowalevskii_Sakowv30012255_NONE ---SLSGR----ASCALDAAMASKPQ---------------------CMAIQPT------ Saccoglossus-kowalevskii_Sakowv30011577_NONE --------------------NTAIPT-------------------GIIRSP--------- Ptychodera-flava_PF12118-t1_NONE ---------------IRNDTKEDEPRGN----------------EEP-----PIN----- Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE ---NIVGR----ASCAVDNTMTSKPQ---------------------CMAIQPP------ Ptychodera-flava_PF18670-t1_NONE --------------------SNPIPT-------------------GIIRAP--------- Acanthaster-planci_oki84-25_NONE ---------------------NTLPS-------------------SQLVNPNPS------ Acanthaster-planci_oki58-6_NONE ----------SSAAVSRSIKRHSLPYFS-----------------QKKAATIPR------ Acanthaster-planci_oki169-35_NONE -----------------VSAWRGVP-------------------------LLPI------ Acanthaster-planci_oki20-22_NONE AEGNGCGI-----MDSGQLPWLNTPPSV-----------------SSSDASNPD------ Acanthaster-planci_oki15-190_NONE ----------------SCSVGSPVPT-------------------SLLRAA--------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte -------------QQQHDEGQLPSPSDSITANADSKTIHYRSSAGMVVDLPTPS------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara SSHSPSG-------HP-SYLDTHPFA---------------------FGAAHAAGLLSSQ Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte -------------PH-VSSPQSPLPT-------------------GLFRNPHPTA---SH Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like CKNDTVGL-----NPPGTAVLPSYPA---------------------VSSFHTG------ Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like -----------------ARPEWRSPSK-----------------------TRPSGDDDD- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -------------THMSGTMGTGLPH-------------------QFLRTTAPA------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -------------THMSGTMGTGLPH-------------------QFLRTTAPA------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like CKNDAVGL-----NAPGTAVLPSYPA---------------------VSSFHTG------ Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo -----------------ARPEWRSPSK-----------------------TRPSGDEDDN Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -------------THMSGTMGTGLPH-------------------QFLRTTAPA------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -------------THMSGTMGTGLPH-------------------QFLRTTAPA------ Oikopleura-dioica_GSOIDT00014261001_NONE -------------TYSPYSTTQMMPNYN----------------PDTLYQAQPT------ Oikopleura-dioica_GSOIDT00006159001_NONE -----------------DSAYAQNPEY-----------------------NQPF------ Oikopleura-dioica_GSOIDT00004289001_NONE ----------------------YFPL---------------------FLGHTPL------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ----------------------------------------------------PP------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE HSQFLAGLGAASSSQPLSSLFSNTPP---------------------LSAFNPYANFFPY Ciona-savignyi_ENSCSAVT00000020041.1_NONE ----------------------SYP-----------------------QTLQTY------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE --------------H-IQGYNSNSPI-------------------SEFEPN--------- Ciona-intestinalis_ENSCINT00000017704.3_NONE GSQLLAGLGAPSTSQPFSSLFTNSPP---------------------LSAFNPYANFFPY Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ----------------------PNP-----------------------STHTPF------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript --------------H-MPGYVSNSPI-------------------RSLE----------- Botryllus-schlosseri_botctg005874g48703_NONE ------GC---------GPAASACPIY-----------------------PQPY------ Botryllus-schlosseri_botctg007226g53212_NONE GANDFGGG--PSSSRASSFLPPHSPAAL----------------SSLLTSVGPYANFFPY Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------------------SYQ-----------------RKMTTGLPWSSRTS- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -----------SKSGSVLSCWPNS-AAA-----------------ARMAAGNPYLGEEAE Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 -----------------CNTWPSVPSYS----------------SCTVSAMQPM------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -----------------SEVNSNTSS-------------------MFLRGNVP------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -----------------SGMSNGLSS-------------------QFLRGS-PV------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------------------PVAPQYP-----------------PKMGPASWFRPMRT- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------------------SYQ-----------------RKMAAGLPWTSRTS- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ----------GTKSGSVLPCWPNSAAAA-----------------ARMAGANPYLGEEAE Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio -----------------CNTWPSMPSYS----------------SCTVTTVQPM------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti -----------------PEVHASTPG-------------------AFLLGN--------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -----------------AAVSNGLGA-------------------QFFRGS-PA------ 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE GHSEL--------------GHLP--PSHAHALSTL------------------------- Pinctada-fucata_pfu5110-102705t1_NONE QENPR------------------------------------------------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 AYAAA--------------GHTP--VSPLQGLKSH------------------------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI QYNMAQTDIYGTGVGVGGGAGTTGSPQAAYGAAAHQVYHPTPTSPTHQLYTNAVLNAPSA Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF10086-t1_NONE ----------------------------IHAFQS-------------------------- Ptychodera-flava_PF18712-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ------------------------------------------------------------ Acanthaster-planci_oki169-35_NONE ------------------------------------------------------------ Acanthaster-planci_oki20-22_NONE ------------------------------------------------------------ Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara GGAAS--------------FGSL--YSEAAALSSMY---------ASNPCTSAIL----- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte QHNLA------------------------------------------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like RDTAA------------------------------------------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo RDAAA------------------------------------------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------ALQSAY------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE GSAAA--------------AAALGFPPPAAGASSSSLPGGRAEPSSGRPISPLSL----- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE ----A------------------------------------------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE GSAAA--------------AAALGFPSPAAGASSSSLPGGRVDGSSGRPMSPMSL----- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE SYNPY--------------LPAGGRPFVSAAAKDAD--------PSGRLGQTRAL----- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 S----------------------------------------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ---------------------------------------DR------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ------------------------------------------------------------ Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc G----------------------------------------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ---------------------------------------DR------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 1570 1580 1590 1600 1610 1620 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu930-101250t1_NONE ------------------------------------------------------------ Pinctada-fucata_pfu5110-102705t1_NONE ------------------------------------------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------------------------RSPQFCIP-------PPIDMMYQN Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ------------------------------------------------------------ Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI LSYSASGWHNGSGAEY--GLYQNAA---------------------AAYYQPEYIPL--- Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF10086-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18712-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------FP---------------- Acanthaster-planci_oki58-6_NONE --------YRSAEDTFG------------------------------------------- Acanthaster-planci_oki169-35_NONE ------------------------------------------------------------ Acanthaster-planci_oki20-22_NONE ------------------------------------------------------------ Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte --------------------------------------------------EP-------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----------------------NGH--------------------------PR------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte -------------------------------------------------STAHGMA---- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------SVSP-------- Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ----MNDW------------CQN------------------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE ----ANRLYRQ----------TNGHHHSFNKTFTDQSSPPLLVPGMLPSSSPRIGANY-- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000003855.1_NONE -------------------------------------------------HSAHYIP---- Ciona-intestinalis_ENSCINT00000017704.3_NONE ----ANRLYRQ----------SNHQQHSFNKSFTDPSSPPLHIPGVLPSSSPRVGTSYSN Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript --------------------------------------------------QPEYFY---- Botryllus-schlosseri_botctg005874g48703_NONE -DCDGPGIHRHS-------LIQSNTRGSY------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE ----AESLYRHS-AKFGKGESQSGHNLS------------------LHTKAPTLTTGH-- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ------------------------------------------------------------ Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ------------------------------------------------------------ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ---------------------------------------VRNDS-R-------------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 -----LYYPHHSPINR----------TSPASSFL----------------PVSTT---SG Crassostrea-gigas_EKC28765_Brachyury-protein -----------YPFTSS---------NTSISSVP---------------NVTVSNP---- Pinctada-fucata_pfu26-120078t1_NONE -----------LPNDRS--------------------------------LYSLYGG-LFG Pinctada-fucata_pfu930-101250t1_NONE -------SQFPLPS----HPLMQPNYSSLSSSLN-ARTPSSPSQ-LP------------- Pinctada-fucata_pfu5110-102705t1_NONE ----KRMRYESFP--------------------------VENDS-HSIDRDTISQQ-NN- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ---------NSLPA------------------------------------APTVPG---- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -----------MPM----DLLAHWQMATLFPQFSMALN------------SPAAA---AS Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -------AIQASPMY-----------------------------------PPAAML-QAG Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -------PPQILPM------------------------------------PPATY----- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 -----RFSPYSLP-------------GSLGSAFD-AVTPGSNAN-RSGD-PPGGG---GG Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -----EIGYATHPLEPV---------DVSK-TLD-------------DPQAAMYKP---- Saccoglossus-kowalevskii_Sakowv30002752_NONE ---RTHGNFYSYPHTYY-----------------------------GADGYP-------- Saccoglossus-kowalevskii_Sakowv30012255_NONE -----HMTQSYMPCNN----------KSTSGVFP----------------VAMYS---TN Saccoglossus-kowalevskii_Sakowv30011577_NONE --------YGSIPATMS---------GTNS-L--------------HSGHSPIYES---- Ptychodera-flava_PF12118-t1_NONE ---RPHGNFYGYPHSYY----------------------------GGGEGYPGQAY---- Ptychodera-flava_PF10086-t1_NONE -----------FPF----DDIMEYTTSKSGKRL--------------------------- Ptychodera-flava_PF18712-t1_NONE -----HMTQGYMPCNN----------KP-NGVFP----------------VPMYS---SN Ptychodera-flava_PF18670-t1_NONE --------YATIPAS------------TGS-LH-------------HTGHSPVYEN---- Acanthaster-planci_oki84-25_NONE -------DLGQSPMTNGT---------------------------CAADTYPTYHP---- Acanthaster-planci_oki58-6_NONE ---KSLDLHGHVPRRHSI-VEGSPLFRASTGNLR-----------GKLEAEPTVQV--SG Acanthaster-planci_oki169-35_NONE -----------SPSGLS--------------------------------FYPMY------ Acanthaster-planci_oki20-22_NONE -----------LPATKR--LRISPASSGSSSATSGSSVLTSGSS-ASTCPPPLTSG--PS Acanthaster-planci_oki15-190_NONE --------YTNY---SQ---------PSTS-S-----------------ITGVHRP---- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ---SPQLDFPHFPSMHT-----STACPDTHKLLDRQDMTWLNTP-PSSDCSPDSKSNSSD Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----LRFSPYHLP-------VTSTTMVTTANPLA-TPIPYESAL-HSSL-SAFGG---SS Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------PVASGLPSAAV---------TTAN-SSEA-----------HALSQSVMAP---- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like -----------LPVSN----------------------------------APLYA---SG Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ----KRLRTEELPPNYD---------ETSGNNYD-----VYNDQ-SGDATSSFAQP-PEH Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform -------PYHSIPTCTV---------PTTA-S-----------------SSPVYHD---- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform -------PYHSIPTCTV---------PTTA-S-----------------SSPVYHD---- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like -----------LPVSN----------------------------------PPLYA---SG Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ----KRLRTEELPPYHD---------ATPGNNYD-----VYDDQ-PGDGTSSFGQQ-QDH Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo -------PYHSIPTCTV---------PTTA-S-----------------SSPVYHD---- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo -------PYHSIPTCTV---------PTTA-S-----------------SSPVYHD---- Oikopleura-dioica_GSOIDT00014261001_NONE --------YITVPTSMY----------------------------DNLQSSDIYAE--PG Oikopleura-dioica_GSOIDT00006159001_NONE -------TPDSLPDSSN--------LYAEAATCI----------------YPMIGSAIEG Oikopleura-dioica_GSOIDT00004289001_NONE ----ARQILQSVPV------------VPLGPIFQ-------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------GYYSTGLEDSS---------PGSAVSFA-------------SEQSCL------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE NAKNSRFSPYAMPFFGFPSFRTHPGNEANGNRFDFSQLPRTQQS-DSND-SKCRR---SG Ciona-savignyi_ENSCSAVT00000020041.1_NONE -----------SPVLT----------------------------------PP------SD Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------NPYEMSPQDCL---------NVAA-TEE-------------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE SAKNSRFSPYAMPFFGFHPFRSGPGTESSENRFDFSHHPRPQPS-ESSEPSQRRR---SG Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri -----------VPV--------------------------------------------SG Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------RGYDVSQQNYV---------TMTS-ADV-------------------------- Botryllus-schlosseri_botctg005874g48703_NONE ---NYEYREEYLPHDEQL------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ----SRFSPYHIPK---------------GSHLDYAGHRSSVHI-D----SPSSK---YG Botryllus-schlosseri_botctg002459g63408_NONE --------YVIX------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ------------P------------PGFSEDQLSKEKVKEEIGS-SWIETPPSIKS---- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ----LAPERSPLP--------------GAEDS----KPKDLSDS-SWIETPSSIKS---- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 -----------LPYQHF------------SAHFT---------------SGPLMPR-LSS Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 -----------LPTVSS---------SVQI-PLQ-------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra -------HYTALPHPVT---------ATTS-T------------------SPLYDG---- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -----------LPMEPG--------PGGSEGR----GPEDQGPPLVWTEIAP-IRP---- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ------------P------------TVFSEDQLSKEKVKEEIGS-SWIETPPSIKS---- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ----LAAERSPLP------------PGAAEDA----KPKDLSDS-SWIETPSSIKS---- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio -----------LPYQHF------------SAHFT---------------SGPLVPR-LAG Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------PAVTS---------PPSVLSTQ-------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio -------HYTPLTHPVS---------APSS-S-----------------GSPLYEG---- 1690 1700 1710 1720 1730 1740 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 LL----------QPVSSSLD--LHNVNPQMQSCRLPQQ---------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ----------AASS-SFDTSKFESCDISSFAPNR-------------DVLR--------- Pinctada-fucata_pfu26-120078t1_NONE INTNFMFPSVAFHSLVSAN----------------------------------------- Pinctada-fucata_pfu930-101250t1_NONE ------------GPGIGPIF-------PTRANPRYSP----------------------- Pinctada-fucata_pfu5110-102705t1_NONE ----------------------TNFQDFQSVE-NFYQNSDFQ------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa -----------FANLAS------------------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 LL----------SKHLAKAS-------SECKVEATSE----------------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN LGPH---PGLNLPPGVSGAD-------LISDESGAEEL---------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------APTVAPVS-------PVASQP--------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 GL----------GGGVVENG-------P--RSLSSSP----------------------- Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ----------SDEQGSVITLECASSSLKSSHDIKIESSSLEHAGERGTVGGGAAVVSV-- Saccoglossus-kowalevskii_Sakowv30002752_NONE --------------------HFAEYPSIPGAEVHYGNY---------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE EH----------HPHSHHHH-------PTSTIPHVHT----------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ----------SHTD---VPDTYTTHQTLSAPK---------------------------- Ptychodera-flava_PF12118-t1_NONE -------------------QHYNEYQTVPVGEVHYGNY---------------------- Ptychodera-flava_PF10086-t1_NONE -------------PVVVNFY-------PFQKKIEYGE----------------------- Ptychodera-flava_PF18712-t1_NONE D------------PHSHSHSX-XXXXXXTSALSHVHSQ---------------------- Ptychodera-flava_PF18670-t1_NONE ----------ASSD-ISVADAFAAHHTATASKA--------------------------- Acanthaster-planci_oki84-25_NONE --------DNQYSYGPSCYFRSNTRPTPYSRDVSYMRDTRYC------------GNGL-- Acanthaster-planci_oki58-6_NONE DFLL---SPSNVSGVAASRADHISGSFPAVTTDAVSAGASSST---------YAPTCLT- Acanthaster-planci_oki169-35_NONE -------------SMVSSSE---------------------------------------- Acanthaster-planci_oki20-22_NONE VSFQHG----MDSSISTEGALQCSDRSLAMGQLRYYGVGENF------------------ Acanthaster-planci_oki15-190_NONE ----------PVGS-MSSCAGYQNYGSPSEAQAGLSTTDTS------------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte SGGQ------AAKRQKMSEEQLSEGTSPKLSDPGDQSNGATSYELTSTIDHGYI------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara LL----------TAASASTS-------P-----TSSS----------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ----------ISVP-ISTVAGHDMSGSPAAVHCHQTGYQDSY---HGDITGSSVGLDVSG Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like GT----------PPQRSYDV-------YPTGLFAAPT----------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like MQYHR-----YNGYYSANPEDYGHYYDRNSMQYGYYGNQGYQ------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ----------SHEV-SSTDSGYGHSTTPPATQTRIPAN---------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ----------SHEV-SSTDSGYGHSTTPPATQTRIPAN---------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like GT----------PPQRSYDV-------YPTGLFAAPT----------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo MQYHR-----YNGYYSANPEDYGHYYDRNAMQYGYYGNQGYQ------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ----------SHEV-SSTDSGYGHSTTPPAPQTRITSN---------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ----------SHEV-SSTDSGYGHSTTPPAPQTRITSN---------------------- Oikopleura-dioica_GSOIDT00014261001_NONE VG--------CKREAGAFYDEYNEESLPKIAKLEPSES---------------------- Oikopleura-dioica_GSOIDT00006159001_NONE LGFQ--------NHGFENQHQQYHNFYEHQTQNHYQS----------------------- Oikopleura-dioica_GSOIDT00004289001_NONE -------------------------QNPLAEKLYLEA----------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ---------------PGIDQFYNGYGTAFRRHVRKRSE---------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE SG----------SPMSSSSS-------PTTRVRTISE----------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE MT----------LAMRKKDT-------PPQK----------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ---------------NTITASLYHSPSPPSAELGQSSP---------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE SG----------SPISSSSS-------PAPRVRTISE----------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri VT----------SETEQKYD-------FPSK----------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ---------------SNVTSSLYETPSPGVMQRPQED----------------------- Botryllus-schlosseri_botctg005874g48703_NONE ------------VNNGCAADQWYNNHVPLAGQVITNPY--------------CIGNDL-- Botryllus-schlosseri_botctg007226g53212_NONE DS----------RHNVSSASS-VSNGSPTRSIMRVDSS---------------------- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin --------LDSNDSGVYTGACKRRRLSPSTSS-NENSP---------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 --------IDSTDSGIYEQA-KRRRISPSDTPVSESSS---------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 VANH---T----SPQIGDTHSMFQHQTSVSHQPIVRQC---------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ---------------ATVSGGMETQGEAPLVRLA-------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ----------GAPA-DLPDSQYD-----ASAHTRLAS----------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------ESSDSGLGEGDSKRRRVSPYPSS-GDSSS---------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin --------LDSNDSGVYTSACKRRRLSPSNSS-NENSP---------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc --------IDSSDSGIYEQA-KRRRISPADTPVSESSS---------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio MANH---G----SPQLGE--GMFQHQTSVAHQPVVRQC---------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ---------------APTSAGVEVLGEPSLTSIA-------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ----------AAAATDIVDSQYD-----AAAQGRLIA----------------------- 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 --------------------------------NRLYT----------------------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ----TSDCALRQPSGHLPSSHNY-GIRTTP-------PTQ----------HPSLPSCTYM Crassostrea-gigas_EKC28765_Brachyury-protein ----------------------TSAWSPLT-------PPPI------------------- Pinctada-fucata_pfu26-120078t1_NONE ---------------------NLR-LRDSI-------PASAS---------------TYT Pinctada-fucata_pfu930-101250t1_NONE ----YALSMSKSPSDS--SSRDM-NISSAS-------PPSNGGISRPSPIRPRSPLGHHL Pinctada-fucata_pfu5110-102705t1_NONE ------------DHYRRQNENLRCPLPETQV-NTVY------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 --N----------------------------------PAEIS------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ---------------------NMN-VNK-------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ----DSEEAEK------------------------------------------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ----ELDVGSETSTLE--------QSTQEQ-------PLE-------Q------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -------VGSSTPT--------------TS-------PRP-------S------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 ----RPRPASHSPPTRPIS------MSPTT-------PPS----------LMKQPRGGGA Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI -----PTAVVNGAP-----AVAADTWTPLT-------PPQSTLQ---------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE -------------------------------------PQISN------------------ Saccoglossus-kowalevskii_Sakowv30012255_NONE ----QSHVQQL-QQTNIPTCHAL-AGTSSI-------PSQFL------------------ Saccoglossus-kowalevskii_Sakowv30011577_NONE -----------------------QGWNPLT-------PPLVX------------------ Ptychodera-flava_PF12118-t1_NONE -------------------------------------PPISG------------------ Ptychodera-flava_PF10086-t1_NONE ----IISCATLSPQSRRVSCQEC-EISAA------------------------------- Ptychodera-flava_PF18712-t1_NONE ----QSHVQSLSQQTTIPTCNAL-SASTSI-------PGQFL------------------ Ptychodera-flava_PF18670-t1_NONE -----------------------NGWSPLT-------PPSV------------------- Acanthaster-planci_oki84-25_NONE ------------------------GYMGRTNPQFAYDPSTMMGGID-------------- Acanthaster-planci_oki58-6_NONE ----RPQREKKNTYKTKKQINEQDSLQPDVNPG----PRNLELTN--------------- Acanthaster-planci_oki169-35_NONE ---------------QDKTSFDLRSVRRSIQ-EDEWFPVS-------------------- Acanthaster-planci_oki20-22_NONE ------------------------AYQNNS-------PMNYSYMGQ-------------- Acanthaster-planci_oki15-190_NONE --GTYPAIANQLCP-----GK-VGAWSPLT-------PPSPGMX---------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ----NQEGAKHNYPQTNIHAQSNAPHQVFQPYGNMYFPQSFP--------SFPSQPSTMN Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ----SSLPASKDVPTSPARS-----ISAAT------------------------------ Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte YGNCHTSTHHQNSPHHQLIGKSVSSWNPLT-------PPSV------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ----AYEPLDYATTCKMAGFS---RMQMSV-------APA-------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ----ASAHAQFVDSEKFAHAHYNGSYHQAQY-NGGYMPTSTA------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------NWSPMT-------MPSM------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------NWSPMT-------PPSL------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ----AYEPLDYATTCKMAGFS---RMQMSV-------APA-------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ----ASAHAQFVDSEKFAHAHYNGAYHQAQY-NGGYMPTSTA------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------NWSPMT-------MPSM------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------NWSPMT-------PPSL------------------- Oikopleura-dioica_GSOIDT00014261001_NONE --------------------------------LASFLPRLSX------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------FYQDSF----GFAPEPIL------------------ Oikopleura-dioica_GSOIDT00004289001_NONE -------------------------LRAKL-------P---------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE -------------P--------GPELSTLV-------GPRC------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE ----SSDGAKVEPCNRSPSGYHSPSISSAV------------------------------ Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------NPATSSP------------LKVAS-------PPT-------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE -------LADAYDP-----TKLTSNWTPLT-------PPSL------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE ----SSDGMKPEPCRRSSNTYPSPTIGTAV------------------------------ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------HDLDSST------------LTNTS-------PTN-------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ---------------------FSIAYTPLT-------PPSL------------------- Botryllus-schlosseri_botctg005874g48703_NONE -------------------------------------PVCGSLAAP-------------- Botryllus-schlosseri_botctg007226g53212_NONE ----DGDSEMKEEPVSPKSM----SRRSAV------------------------------ Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin -------------------------------------SMKCE--------DINAEDYSKD Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 -------------------------------------PLKSE--------VLTQRDCDKT Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ----GPQTGIQSPPSSLQPAEFL--YSHGV-------PRTLS------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ----------------------DSAWT--S-------SHSF------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------MWTPIT-------PPSM------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti -------------------------------------PAGAP--------SPFDKEAEG- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin -------------------------------------SIKCE--------DINAEEYSKD Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc -------------------------------------PLKSE--------VLAQRDCEKN Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ----GPQTGLQS-PGTLQPPEFL--YSHGV-------PRTLS------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ----------------------VSTWTAVA-------SHPFAGWG--------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------SWTPVS-------PPSM------------------- 1810 1820 1830 1840 1850 1860 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 QPAQPYPTHLAPNVHMM---------NMNFT----------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE SPE-PTGLHHPPAAYRY---------HPYLTP------------------DKISAAQ--- Pinctada-fucata_pfu930-101250t1_NONE SPG-SSGTNPTSELKSM---------ELMLN-----GLD--------------------- Pinctada-fucata_pfu5110-102705t1_NONE ------------------------------------------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ------------------------------------------------------------ Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 -----------PEVKKE---------QKSVTPPKKGGFDV------------LDLLS--- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN -----------PSTRSK---------GFSISAILGGGS---------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN -----------TSTKRN---------SFSISAILAY------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 GAGVAQSQHSPSELKSM---------EKMVN-----GLEVQHNGSAAAAAAALQLAEEAA Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE ----YNGGYX-------------------------------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE -----HTHTNTATMGM----------NVHMSS---------------------------- Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ----FGGTY--------------------------------------------------- Ptychodera-flava_PF10086-t1_NONE -------------VKRI---------DLMVT-----TAD--------------------- Ptychodera-flava_PF18712-t1_NONE ----PATYTNTPTMAVIKLAKAFRNDNVLITS----GLYIRLR---------VSLAS--- Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ----PRRNYT----------------QHMVX----------------------------- Acanthaster-planci_oki58-6_NONE ----PX------------------------------------------------------ Acanthaster-planci_oki169-35_NONE --------HAFRESHRY---------HKHLAQ------------------GPY-ASI--- Acanthaster-planci_oki20-22_NONE ----PRAGLNLPTTTPYYF----QQNNX-------------------------------- Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte GYNIPQQPY--NSINNMLC-----HGQSYPNA---------------------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara -----------NELQSI---------QKMVS-----GLD--------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ----PHLSHF-PTSSAT---------TMPVN--FHGMFNT-------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like SAETASGHY--------------------------------------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ----PHLSHF-PTSSAT---------SMPVN--FHGMFNT-------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo SAETATGHY--------------------------------------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE --------------------------NQNLDQNLITFLEX-------------------- Oikopleura-dioica_GSOIDT00004289001_NONE --------------------------NFX------------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE --------YRLARFKLLVX----------------------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE -----------QELRNM---------ENLVS-----GLD--------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ----PHTIY-----SML---------HANTS--QRKHSSI-------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE -----------QELRNM---------ENLVS-----GLD--------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ----AQSIY-----SML---------HANTN--WNNPFNV-------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE --------------------------RRHVVX---------------------------- Botryllus-schlosseri_botctg007226g53212_NONE -----------HEIRNM---------ERLVS-----GLERR------------------- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin TSKGM-GYY-----------------AFYTSS---------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 CAKDI-GYY-----------------GFYSHS---------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ----PHQYHSVHGVGMVP--------EWSENS---------------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------QFY-----------------NYFPN----------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin TSKGMGGYY-----------------AFYTTP---------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc CAKDISGYY-----------------GFYSHS---------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ----PHQYHSVHGVGMVP--------EWSDNS---------------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti GPG-AGGHHSPSSLDG-------------------------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+ Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ------------------------------------------------------------ Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ------------------------------------------------------------ Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ------------------GPMA-------------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ------------------------------------------------------------ Pinctada-fucata_pfu26-120078t1_NONE ------------------KSAESSVTDTCR-P---------------------------- Pinctada-fucata_pfu930-101250t1_NONE ------------------RKKGPHRDPNS------------------------------- Pinctada-fucata_pfu5110-102705t1_NONE ------------------------------------------------------------ Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 -----------------IKSE--------------------------------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ------------------------------------------------------------ Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ------------------KP---------------------------------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ------------------------------------------------------------ Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 QHHHHTQAHHQQQQHQSHHQQQHHQQPAQPHPHHQTHLHSHHGATTGGTDQXQLLDGRSD Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30002752_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30012255_NONE ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30011577_NONE ------------------------------------------------------------ Ptychodera-flava_PF12118-t1_NONE ------------------------------------------------------------ Ptychodera-flava_PF10086-t1_NONE ------------------RSMSAIDRP--------------------------------- Ptychodera-flava_PF18712-t1_NONE ------------------SSQPDSRSV----PMKRYTVWSRCGTFQS-TGRTGIGSTREH Ptychodera-flava_PF18670-t1_NONE ------------------------------------------------------------ Acanthaster-planci_oki84-25_NONE ------------------------------------------------------------ Acanthaster-planci_oki58-6_NONE ------------------------------------------------------------ Acanthaster-planci_oki169-35_NONE ------------------KTTRSASTLFAP-PS--------------------------- Acanthaster-planci_oki20-22_NONE ------------------------------------------------------------ Acanthaster-planci_oki15-190_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ------------------KTQK-------------------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ------------------HPMPAAYPG-------------HAGKFAA------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ------------------------------------------------------------ Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ------------------HPMPAAYPG-------------HAGKFAA------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00014261001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00006159001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00004289001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00007455001_NONE ------------------------------------------------------------ Oikopleura-dioica_GSOIDT00000279001_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000016577.1_NONE ------------------KARRH------------------------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ------------------STKPCDQ----------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000017704.3_NONE ------------------KTRRHS------------------------------------ Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ------------------SKTNSEY----------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ------------------------------------------------------------ Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ------------------------------------------------------------ Botryllus-schlosseri_botctg005874g48703_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg007226g53212_NONE ------------------NKISSEX----------------------------------- Botryllus-schlosseri_botctg002459g63408_NONE ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ------------------------------------------------------------ Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ------------------------------------------------------------ Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ------------------------------------------------------------ Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ------------------------------------------------------------ Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ------------------------------------------------------------ Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ------------------------------------------------------------ Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ------------------------------------------------------------ 1930 1940 1950 1960 1970 =========+=========+=========+=========+=========+== Crassostrea-gigas_EKC28235_T-box-brain-protein-1 ---------------------------------------------------- Crassostrea-gigas_EKC26469_T-box-transcription-factor-TBX2 ---------------------------------------------------- Crassostrea-gigas_EKC20476_T-box-transcription-factor-TBX2 ---------------------------------------------------- Crassostrea-gigas_EKC28765_Brachyury-protein ---------------------------------------------------- Pinctada-fucata_pfu26-120078t1_NONE ---------------------------------------------------- Pinctada-fucata_pfu930-101250t1_NONE ----------LLMEK------------------------------------- Pinctada-fucata_pfu5110-102705t1_NONE ---------------------------------------------------- Caenorhabditis-elegans_T27A1.6_mab-9-T-box-protein-12 ---------------------------------------------------- Caenorhabditis-elegans_H14A12.4_mls-1-T-box-transcription-fa ---------------------------------------------------- Caenorhabditis-elegans_F21H11.3.1_tbx-2-T-box-protein-2 ---------------------------------------------------- Drosophila-melanogaster_FBtr0076547_Doc2-Dorsocross2-DBNLIN ---------------------------------------------------- Drosophila-melanogaster_FBtr0076522_Doc1-Dorsocross1-DBNLIN ---------------------------------------------------- Drosophila-melanogaster_FBtr0331162_bi-bifid-DBNLINE-60 CEDAGLELELELEEDVEDLDQDPDEQDEDRSSVID----------LDLDVDV Drosophila-melanogaster_FBtr0332070_byn-brachyenteron-DBNLI ---------------------------------------------------- Saccoglossus-kowalevskii_Sakowv30002752_NONE ---------------------------------------------------- Saccoglossus-kowalevskii_Sakowv30012255_NONE ---------------------------------------HFPTHTMKFSAX- Saccoglossus-kowalevskii_Sakowv30011577_NONE ---------------------------------------------------- Ptychodera-flava_PF12118-t1_NONE ---------------------------------------------------- Ptychodera-flava_PF10086-t1_NONE -----------IWQKLSLINCNKNQKQQSAN--------------------- Ptychodera-flava_PF18712-t1_NONE AYHIKPVIGRFIERHLDDLNCRNC---FVRSYFIDSFTRYFRVSTLWLNSK- Ptychodera-flava_PF18670-t1_NONE ---------------------------------------------------- Acanthaster-planci_oki84-25_NONE ---------------------------------------------------- Acanthaster-planci_oki58-6_NONE ---------------------------------------------------- Acanthaster-planci_oki169-35_NONE -----------LVRX------------------------------------- Acanthaster-planci_oki20-22_NONE ---------------------------------------------------- Acanthaster-planci_oki15-190_NONE ---------------------------------------------------- Strongylocentrotus-purpuratus_SPU025584-tr_SP-TBR-Uncharacte ---------------------------------------------------- Strongylocentrotus-purpuratus_SPU023386-tr_SP-TBX2-3-Unchara ---------------------------------------------------- Strongylocentrotus-purpuratus_SPU013015-tr_SP-BRA-Uncharacte ---------------------------------------------------- Branchiostoma-belcheri-1_XP019614038.1_109461997-T-box-containing-protein-TBX6L-like ---------------------------------------------------- Branchiostoma-belcheri-1_XP019632778.1_109476306-brachyury-protein-like ---------------------------------------------------- Branchiostoma-belcheri-1_XP019623304.1_109469262-brachyury-protein-homolog-2-isoform ---------------------------------------------------- Branchiostoma-belcheri-1_XP019623300.1_109469259-brachyury-protein-homolog-1-isoform ---------------------------------------------------- Branchiostoma-floridae-rs_XP035691536.1_118426331-T-box-containing-protein-TBX6L-like ---------------------------------------------------- Branchiostoma-floridae-rs_XP035658836.1_118404018-T-box-transcription-factor-T-homolo ---------------------------------------------------- Branchiostoma-floridae-rs_XP035687366.1_118423359-T-box-transcription-factor-T-homolo ---------------------------------------------------- Branchiostoma-floridae-rs_XP035687472.1_118423429-T-box-transcription-factor-T-homolo ---------------------------------------------------- Oikopleura-dioica_GSOIDT00014261001_NONE ---------------------------------------------------- Oikopleura-dioica_GSOIDT00006159001_NONE ---------------------------------------------------- Oikopleura-dioica_GSOIDT00004289001_NONE ---------------------------------------------------- Oikopleura-dioica_GSOIDT00007455001_NONE ---------------------------------------------------- Oikopleura-dioica_GSOIDT00000279001_NONE ---------------------------------------------------- Ciona-savignyi_ENSCSAVT00000016577.1_NONE ----------------EELRLNKV---------------------------- Ciona-savignyi_ENSCSAVT00000020041.1_NONE ---------------------------------------------------- Ciona-savignyi_ENSCSAVT00000003855.1_NONE ---------------------------------------------------- Ciona-intestinalis_ENSCINT00000017704.3_NONE ----------------EELRVNKA---------------------------- Ciona-intestinalis_ENSCINT00000037322.1_tbx6a-T-box-transcri ---------------------------------------------------- Ciona-intestinalis_ENSCINT00000034896.1_NONE ---------------------------------------------------- Ciona-intestinalis_ENSCINT00000001477.3_brachyury-transcript ---------------------------------------------------- Botryllus-schlosseri_botctg005874g48703_NONE ---------------------------------------------------- Botryllus-schlosseri_botctg007226g53212_NONE ---------------------------------------------------- Botryllus-schlosseri_botctg002459g63408_NONE ---------------------------------------------------- Gallus-gallus-E102_ENSGALT00000042658.4_EOMES-eomesodermin ---------------------------------------------------- Gallus-gallus-E102_ENSGALT00000067150.2_TBR1-T-box-brain-1 ---------------------------------------------------- Gallus-gallus-E102_ENSGALT00000013434.6_TBX5-T-box-5 ---------------------------------------------------- Gallus-gallus-E102_ENSGALT00000024597.4_TBX19-T-box-19 ---------------------------------------------------- Gallus-gallus-E102_ENSGALT00000018726.5_TBXT-T-brachyury-tra ---------------------------------------------------- Homo-sapiens-E102_ENST00000177694.2_TBX21-T-box-transcripti ---------------------------------------------------- Homo-sapiens-E102_ENST00000449599.4_EOMES-eomesodermin ---------------------------------------------------- Homo-sapiens-E102_ENST00000389554.8_TBR1-T-box-brain-transc ---------------------------------------------------- Homo-sapiens-E102_ENST00000405440.7_TBX5-T-box-transcriptio ---------------------------------------------------- Homo-sapiens-E102_ENST00000367821.8_TBX19-T-box-transcripti ---------------------------------------------------- Homo-sapiens-E102_ENST00000366876.7_TBXT-T-box-transcriptio ----------------------------------------------------