Selected Residue / Sequence Deleted Residue / Sequence 10 20 30 40 50 60 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g3510.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g17034.t1_NONE ------------------------------------------------------------ Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE -----------------------------------MILGSCNPYISYIRISPPPS----- Drosophila-melanogaster_FBtr0079335_eyes-absent MVTLMPYNYAAPRCGLIDKMIEPKVKRPKTDHTDTHERNRLCNLSQQQQQQQPQQQQTHQ Saccoglossus-kowalevskii_Sakowv30018491_NONE -----------------------------------------------MEIQSP------H Ptychodera-flava_PF33570-t1_NONE ------MDSESVSQTSSELELDLERPVKRARHESESITDNHSAGSRSMEIQSPPS--QGQ Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ------------------------------------------------------------ Acanthaster-planci_oki48-14_NONE ----------MLHARPPKICLLNKVKRARIESEGANENHTQSSSRSMEIQQLASPHSQVS Branchiostoma-floridae_BRAFL83679_NONE ------------MQCLYHAAPVYQ--VKKARHEELSDSPAN-RLMDSQQLSSPGH----Q Branchiostoma-belcheri_BRBE223870R-t1_NONE ----------MMMMEEPQASDLHDRPVKKARHEELSDSPANSRLMDSQQLSSPGH----Q Oikopleura-dioica_GSOIDT00002684001_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- ---------------MEEPQDLPEQPVKKAKMQESREQSLSHVSNTEVSDQKAES----- Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- ---------------MEDPQGINGKAVQKSQTSSDVAVSSSCRSMEMQDLASPHSRLSGS Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- ---------------MEDSQDLSEQSVKKTCTESDVSEPPNARSMEMQDLASPHN-LVGS Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a ------------------------------------------------------------ Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ---------------MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPET----- Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac ---------------MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHT-LVGG Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac --------------------------------------------MEMQDLTSPHSRLSGS Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac ------------------------------------------------------------ 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g3510.t1_NONE -----------------------------------------------------------M Praesagittifera-naikaiensis_g17034.t1_NONE -----------------------------------------------------------M Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE ---PVVKRLRKENHHFDINLVNH------------------------------------- Drosophila-melanogaster_FBtr0079335_eyes-absent QQQQQQQQSHQQSHSSTVLASNGPSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQ Saccoglossus-kowalevskii_Sakowv30018491_NONE SGNGNSPIQRENTDNTSCI--NG------------------------------------- Ptychodera-flava_PF33570-t1_NONE SGNNNSP-QTENTDNTSCITTNG------------------------------------- Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ------------------------------------------------------------ Acanthaster-planci_oki48-14_NONE SANGNSPQHDNSTDSNCSVTTNG------------------------------------- Branchiostoma-floridae_BRAFL83679_NONE TGNGNSPSSIANASYAT----NG------------------------------------- Branchiostoma-belcheri_BRBE223870R-t1_NONE TGNGNSPSSIANASYAT----NG------------------------------------- Oikopleura-dioica_GSOIDT00002684001_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- ------------------------------------------------------------ Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- SESPSGPKLDNSHINNNSMTPNG------------------------------------- Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- SDAPGSSKLDKPNLSSTSVTTNG------------------------------------- Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a ------------------------------------------------------------ Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ------------------------------------------------------------ Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac GDTPGSSKLEKSNLSSTSVTTNG------------------------------------- Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac SESPSGPKLGNSHINSNSMTPNG------------------------------------- Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac ------------------------------------------------------------ 130 140 150 160 170 180 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE -------------------MVVLAPPNLFLLTA-----PCNVRYSQLVE----------Y Praesagittifera-naikaiensis_g3510.t1_NONE YSSSNSATGSLTGIDVSQENTILHNPSLLPAISSVPLPPNNSSNNQLSSSLFKNDSLSFY Praesagittifera-naikaiensis_g17034.t1_NONE YSSSNSATGSLTGIDVSQENTILHNPSLLPAISSVPLPPNNSSNNQLSSSLFKNDSLSFY Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE ------ARGKGSALELHGLEDTVPSLIDSNHNSPLDQSASALDSPTLENHPLSISTNGTA Drosophila-melanogaster_FBtr0079335_eyes-absent SQPLQPTIGSLASLSGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGG Saccoglossus-kowalevskii_Sakowv30018491_NONE ------TEGNRGPMSTSEDNSILSNPD---AWASVQTTAS-IKTEPIVND----TVSTDT Ptychodera-flava_PF33570-t1_NONE ------TEGNRAPLSSSADNSVLQTPE---NWASVQTTASTVKTEPIVHD----SVPTDT Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ------------------------------------------------------------ Acanthaster-planci_oki48-14_NONE ------TEGNHVSMATTAETSVLTSTESWNSVH----SAASIKSEPLSNS--DPSTPTVI Branchiostoma-floridae_BRAFL83679_NONE ------TDTGQGVIVTTGDSTVLTNSDWAMTGVTTQTTAS-VKSEPITCD----APTSGT Branchiostoma-belcheri_BRBE223870R-t1_NONE ------TDTGQGVIVTTGDSTVLTNSDWAMTGVTTQTTVS-VKSEPITCD----APTSGT Oikopleura-dioica_GSOIDT00002684001_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- ----------------------------------------------------------SS Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- ------T---------------------------------EVKTEPMSSSEIATTTTTTT Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- ------TGGDNMTVLNTADWLLSCS-----TPSSATMSLLAVKTEPMNSNE---TTTTTG Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a -------------------------------------------------------MLDLV Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ----------------------------------------------------------SS Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac ------TGGENMTVLNTADWLLSCN-----TPSSATMSLLAVKTEPLNSSE---TTATTG Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac ------T---------------------------------EVKTEPMSSSE---TASTTA Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac -------------------------------------------------------MVELV 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE ELECILLIQVLTYLAMCNI-DAAAYALNAAN----------------------------- Praesagittifera-naikaiensis_g3510.t1_NONE DTLSHQQTSSPTTLNMFNAQSSSSHVLNPSNTQLQTFPANNSLLYNYVGHSNFQSKRFKQ Praesagittifera-naikaiensis_g17034.t1_NONE DTLCHQQTSSPTTLNMFNAQSSSSHVLNPSNTQLQTFPANNSLLYNYVGHSNFQSKRFKQ Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE DGGIASLTSPGDGSTFSNSDSLFIATVGSPIIEDLSKTSSVSDLDSSNLSTFFNSTSGAD Drosophila-melanogaster_FBtr0079335_eyes-absent VSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASN Saccoglossus-kowalevskii_Sakowv30018491_NONE -----NYSGSNTTIEIYSGSGSQNTQQDMSYSRHSKSEYSSQYFPS-HSYPHIIPTPSAQ Ptychodera-flava_PF33570-t1_NONE -----NFTGSNTAIENYTGS-SQTPEQDMSYSRHLKSEYPTQYFPS-HSYPHIIPTPSAQ Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ------------------------------------------------------------ Acanthaster-planci_oki48-14_NONE QDGGYGVNAPLDELAGSNSGVGGQSSLDMNLRQPKSE--FPSQYYPSQAYPHILPTPSAQ Branchiostoma-floridae_BRAFL83679_NONE FTHGADFAGSTESRTMNSQGTSQNSTAYEGTAAQFAASQFPYGSPG-RPYPHILPAPASQ Branchiostoma-belcheri_BRBE223870R-t1_NONE FSHGADFAGSTESRTMNSQGTSQNSTAYEGTAAQFAASQFPYGSPG-RPYPHILPAPASQ Oikopleura-dioica_GSOIDT00002684001_NONE -----------------------------------------------MAYPGIWANSYGQ Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ----------------------------------------------MAAYP--------- Ciona-savignyi_ENSCSAVT00000006529.1_NONE ----------------------------------------------MAAYP--------- Gallus-gallus_ENSGALT00000070785.1_NONE -MPILCWC--CID----------------------------------------------- Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- LGSNLPMSTEIMTCTDYIPRSSNDYT---------------SQMYSAKPYAHILSVPVSE Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- DGSLDNFSGSAIGSSGFSPRQTHQFS-------------PPQIYPSNRPYPHILPTPSSQ Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- DGSLDTFTGSVITSSGYSPRSAHQYS--------------PQIYPS-KPYPHILSTPAAQ Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a ISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFP Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac LASNLPMSEEIMTCTDYIPRSSNDYT---------------SQMYSAKPYAHILSVPVSE Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac DGALDTFTGSVITSSGYSPRSAHQYS--------------PQLYPS-KPYPHILSTPAAQ Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac DGSLNNFSGSAIGSSSFSPRPTHQFS-------------PPQIYPSNRPYPHILPTPSSQ Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac ISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFS-RSCPRVLPRQPST 250 260 270 280 290 300 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g3510.t1_NONE NHDSLDNYNAVDNFDDNVGSNVDGVPQGPVSSLSNTNAFLSTLANSSNPHNCYYSPISAL Praesagittifera-naikaiensis_g17034.t1_NONE NHDSLDNYNVVDNFDDNVGSNVDGVPQGPVSSLSNTNAFLSTLANSSNPHNCYYSPISAL Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE T------VLTSVQTSQDTVVTTSANMSAAYPGFQSPAAGFNY------------------ Drosophila-melanogaster_FBtr0079335_eyes-absent PLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAK Saccoglossus-kowalevskii_Sakowv30018491_NONE GSNTLNYQTTQNQGT--AAYMPANTTTYPYATGQTTGQAASYGLTQPGPYGAPGRGTMAI Ptychodera-flava_PF33570-t1_NONE ANNALGNYQSVAGQTQATAYMQPNATSYPYG---TQSGQTAYGLTQVPYAAAAPGGGSSV Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte --------MTQELHT--SRY---------------------------------------- Acanthaster-planci_oki48-14_NONE G-----------SNYQASQQSTFGVQNSSYPYAGQSSQTPYGLAQAMSYGSKTLKADPAQ Branchiostoma-floridae_BRAFL83679_NONE T----GMPGYQQVVTGQQQYMQPANPGYYNPQTRQPYLPGAY----PP------------ Branchiostoma-belcheri_BRBE223870R-t1_NONE T----GMPGYQQVVTGQQQYMQPANPGYYNPQTRQPYLPGAY----PPGARPAMQEAKGV Oikopleura-dioica_GSOIDT00002684001_NONE MYQGTPGNNNNYAQTSQ------------YPP---------------------------- Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE --------------TMWQQYVYGAGGGYGYG----------------------------- Ciona-savignyi_ENSCSAVT00000006529.1_NONE --------------TMWQQYVYGAGGGYGYG----------------------------- Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- T------MSPYPGQTQYQA-LQQSQPYTIYPQTTQTYGLPPF--GALWPGMKPESGLIQT Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- T------MAAY-GQTQFTTGMQQATAYATYPQPGQPYGIPSY--GALWAGIKTEGGLSQS Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- T------MSAYAGQTQY-SGMQQPAVYTAYSQTGQPYSLPTYDLGVMLPGIKTESGLSQT Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a T-------MATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSY---------SIKTEDSLS Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac T--------AYPGQTQYQT-LQQTQPYAVYPQATQTYGLPPF--GALWPGMKPESGLIQT Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac T------MSAYAGQTQY-SGMQQPAVYTAYSQTGQPYSLPTYDLGVMLPAIKTESGLSQT Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac T------MAAY-GQTQFTTGMQQATAYATYPQPGQPYGISSY--GALWAGIKTEGGLSQS Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac A-------MAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSY---------SIKTEDSLN 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE -------------------------------VPPSLS----------------------- Praesagittifera-naikaiensis_g3510.t1_NONE ANINVNGNSPLESNSQIINASPPVHPDDSRRTPRSLSQGT--LELSRLPDPGRQSPNVQG Praesagittifera-naikaiensis_g17034.t1_NONE ANINVNENSPLESNSQIINASPPVHPDDSRRTPRSLSQGT--LELSRLPDTGRQSPNVQG Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE -------------------QQQAWSYPTDMKQMSAAAGGK--A-ASSVPTAYSPYATGFN Drosophila-melanogaster_FBtr0079335_eyes-absent MEPGAAAAAAAYLTPSYAASGNN--------------------------NSQLYSSPYAG Saccoglossus-kowalevskii_Sakowv30018491_NONE KNNTLTHQGQSNYLPSYTQSGQNALYQVQG----SSYTTS--G-YTYPTATNSSTPT--- Ptychodera-flava_PF33570-t1_NONE KNNPITPAAQSSYLSSYGQTGQNTVYPSQG----GSYTTS--G-YTYPTTSNATNTSA-N Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ----------------YRQTGRKNL--------------------------NPPLEC--- Acanthaster-planci_oki48-14_NONE MQGQGSYLSTYGSAGFTGSSSQAAQSPYYQMQGGSFTGSSYPYPTCSSSTSTTNSQGFNS Branchiostoma-floridae_BRAFL83679_NONE ----------------------------------GTYSTS--A-ATYPTNSPATNTQAYA Branchiostoma-belcheri_BRBE223870R-t1_NONE QGQHGAAYPTGLYGPGFSAAGQPAQAPYTAYQVQGAYSTS--A-ATYPTNSPATNTQAYA Oikopleura-dioica_GSOIDT00002684001_NONE -----------------------------------------------------------S Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE -----------------------------------------------------GHASLSS Ciona-savignyi_ENSCSAVT00000006529.1_NONE -----------------------------------------------------GHASLSS Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- PSTSQHSVLTCTTGLTTSQPSPA---HYSYSIEASTTNAS--PVSTSSTVVNISTSAVAS Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- QSPGQTGFLSYGASFSTPQPGQA---PYSYQMQGSSFTTS--S-GIYAGNNSLTNSTGFN Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- QSPLQSGCLSYSPGFSTPQPGQT---PYSYQMPGSSFTPS--S-TIYA-NNSVSNSTNFS Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a HSPGQSGFLSYGSSFSTPTAGQA---PYTYQMHGTT--------GIYQGANGLTNSAGFS Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac PSPSQHSVLTCTTGLTTSQPSPA---HYSYPIQASSTNAS--LISTSSTIANIPAAAVAS Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac QSPLQSGCLSYSPGFSTPQPGQT---PYSYQMPGSSFAPS--S-TIYA-NNSVSNSTNFS Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac QSPGQTGFLSYGTSFSTPQPGQA---PYSYQMQGSSFTTS--S-GIYTGNNSLTNSSGFN Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac HSPGQSGFLSYGSSFSTSPTGQS---PYTYQMHGTT--------GFYQGGNGLGNAAGFG 370 380 390 400 410 420 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein -------------------MRG-------------------------------------- Praesagittifera-naikaiensis_g3512.t1_NONE -----------------------------------------GF-------GAASLMA--- Praesagittifera-naikaiensis_g3510.t1_NONE SSRSETPE---------------------------GNCPSLGFRQSPQATSAAQLSVNHM Praesagittifera-naikaiensis_g17034.t1_NONE SSRSETPE---------------------------GNCPSLGFRQSPPATSAAQLSVNHM Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE YSNQYLYPQVPFTTTNAS---SSPSSYPPTGDVWNNYY--------YQGLPPVNPSS--- Drosophila-melanogaster_FBtr0079335_eyes-absent YNNFGQQDYGGYYNEQYG-----------------NYYSPANYSPYAVSSPSSS------ Saccoglossus-kowalevskii_Sakowv30018491_NONE AHSYNTTPQVGSVSESNGVDYGTAY-GTAYTQPGYQYYSS-QGYSPYMPGNSTALNNTGT Ptychodera-flava_PF33570-t1_NONE AQAYNTSQQ--------GIDYGTAYPGYGQTAASYPYYTT-QGYSPYMSTNSTSLNTTGS Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte VENTFTTDASIKLDDANGIGRG-------------------------------------- Acanthaster-planci_oki48-14_NONE SPQGEYGSYGTYGQSGFN-----------------QYYPAPGYGSPYMANSALGPTPSSV Branchiostoma-floridae_BRAFL83679_NONE AQ------QAVGKQTQSGQEYTYPPQFGQAGTYAHQYYTTPQGYSPFNTSSTTTLTA--- Branchiostoma-belcheri_BRBE223870R-t1_NONE AQQAAVVLQAVGKQSQSGQEYTYPPQFGQAGTYAHQYYTTPQGYSPFNTSSTTTLTA--- Oikopleura-dioica_GSOIDT00002684001_NONE AQASQQAPISANGQAEYG----------------AQYYATQGHYPNYHNNYYVSSTQPAL Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE GHNMNTSPQDGYGGAGYA-----------------HYYTAPSG---YYGNNSV------- Ciona-savignyi_ENSCSAVT00000006529.1_NONE GHNMNTSPQDGYGGAGYA-----------------HYYTAPSG---YYGNNSV------- Gallus-gallus_ENSGALT00000070785.1_NONE -----------------------------------------------CNSNGLSPS---- Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- IS-QEYPTYTILGQSQYQ-----------------TCYPSSGFGVITPADSNAESTAL-- Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- SSQQEYPSYPSFGQGQYA-----------------QYYNSSPYPSHYMTNSNTSPTT--- Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- SSQQDYPSYTAFGQNQYA-----------------QYYSASTYGA-YMTSNNTADGT--- Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a AVHQEYSSYPSFPQSQYS-----------------QYYSS-SYNSPYMSTNSISPS---- Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ISNQDYPTYTILGQNQYQ-----------------ACYPSSSFGVTGQTNSDAESTTL-- Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac GSQQDYPSYTAFGQNQYA-----------------QYYSASTYGA-YMTSNNTADGT--- Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac SSQQDYPSYPSFGQGQYA-----------------QYYNSSPYPAHYMTSSNTSPTT--- Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac SVHQDYPSYPGFPQSQYP-----------------QYYGS-SYNPPYVPASSICPS---- 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein -----------------------------------R------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE --------------PSTRTREP------CYLKNHKYTLKKN------------------- Praesagittifera-naikaiensis_g3510.t1_NONE LQNPQIHSQYAINRPSSVTVFPQGDLMGCTLKDNLVNHHENFSTMQYYPSVYSQLLASAA Praesagittifera-naikaiensis_g17034.t1_NONE LQNPHLHSQYAINRPSSVTVFPQGDLMGCTLKDNLVNHHENFSTTQYYPSVYSQLLASAA Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE --VA-NPPTYQLMEPPPTSESNFNTQLN-------PSPSPPIRDNSG------------- Drosophila-melanogaster_FBtr0079335_eyes-absent --AS-HGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSA Saccoglossus-kowalevskii_Sakowv30018491_NONE VLPA-TTTTYQLAPLPNEVDPQMATIPADTIVKSEENGRA-------------------- Ptychodera-flava_PF33570-t1_NONE ALPT-TTTTYQLAALPNEVENQLATLQGESVIKTEENGRG-------------------- Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte -----------------------------------RQGQG-------------------- Acanthaster-planci_oki48-14_NONE PT---TTTTYQLAPLPSEKFVESPVLLEGQVAPQDAPSSANEVESSFTTDSSIKLDDANG Branchiostoma-floridae_BRAFL83679_NONE --PS-TTTTYQLQPMPD--------LPTTGVVHEDV------------------------ Branchiostoma-belcheri_BRBE223870R-t1_NONE --PS-TTTTYQLQPMPD--------LPTTGVVHEDV------------------------ Oikopleura-dioica_GSOIDT00002684001_NONE TATSGSQVTYQLQEPPNEAIGEIKYTID-------------------------------- Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE --IT-SPVTYQLQEPPPEHNIEQIKYTV-------------------------------- Ciona-savignyi_ENSCSAVT00000006529.1_NONE --IT-SPVTYQLQEPPPEHNIEQIKYTV-------------------------------- Gallus-gallus_ENSGALT00000070785.1_NONE --LL-PSS---------------------------------------------------- Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- -----ATATYPSEKPNAMVPTRTVQRHSSGDASTSPSLSRATASKE-------------- Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- --PS-TNATYQLQEPPSGITSQAVTDPAAAEYSTIHSPSTPIKDSDS------------- Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- --SS-SSSTYQLQESLPGLTSQPGTDLHSGEFDTVQSPSTPIKDLD-------------- Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a --AI-PTSTYSLQESSHNITSQ-STESLSGEYGT-----TPAKDIET------------- Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac -----AATTYQSEKPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKD-------------- Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac --PS-STSTYQLQESLPGLTNQPGTDLHPGEFDTMQSPSTPIKDLD-------------- Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac --PS-TNATYQLQEPPSGITSQAVTDP-TAEYSTIHSPSTPIKDSDS------------- Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac --PL-STSTYVLQEASHNVPNQ-SSESLAGEYNTHNGPSTPAKEGDT------------- 490 500 510 520 530 540 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein -------------------------------------RSTS-SAPTPELDHS-------- Praesagittifera-naikaiensis_g3512.t1_NONE ---------------------------------------KKCSSPAP------------- Praesagittifera-naikaiensis_g3510.t1_NONE TSGQAAGGQVPGSGSIG-------NPASVGGLFSPPGMVQQYSHPSAAAAVSALYSPYSN Praesagittifera-naikaiensis_g17034.t1_NONE TSGQAVGGQVPGSGSVG-------NTAAVGGLFSPPGMVQQYSHPSAAAAVSALYSPYSN Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE ------------------------SSSEYEKRNNRTRPGRNRQNPSPGPESD-------- Drosophila-melanogaster_FBtr0079335_eyes-absent AAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEA Saccoglossus-kowalevskii_Sakowv30018491_NONE ------------------------SRNRGGNNRRPAARGRR-NNPSPPPEND-------- Ptychodera-flava_PF33570-t1_NONE ------------------------R--NRGNNRRTAGRGRR-NNPSPPPEND-------- Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ------------------------QGPKNGNRTKSAGRSRR-NNPSPPPEDG-------- Acanthaster-planci_oki48-14_NONE RGRQ--------------------GSKGSSARNRGTGRGRR-NNPSPPPEDG-------- Branchiostoma-floridae_BRAFL83679_NONE ---------------------------TKVKSTPSRSKSRR-KQPSPPPEND-------- Branchiostoma-belcheri_BRBE223870R-t1_NONE ---------------------------TKVKSTPSRSKSRR-KQPSPPPEND-------- Oikopleura-dioica_GSOIDT00002684001_NONE ------------------------DTDRRRGGKKSKKRDIE------NGDNE-------- Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------DDLDRRKGGKSKTRNSR-KNPSPGPDAQ-------- Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------DDLDRRKGGKSKTRNSR-KNPSPGPDAQ-------- Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- ------------------------SDEQARKNIPGKNRGKRKADTSSSQDSE-------- Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- ------------------------DRLRRSSDGKSRGRGRRNNNPSPPPDSD-------- Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- ------------------------ERTCRSSGSKSRGRGRK-NNPSPPPDSD-------- Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a ------------------------DRHHRGSDGKVRARSKRSNDPSPTADSE-------- Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ------------------------TDDQSRKNMTSKNRGKRKADATSSQDSE-------- Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac ------------------------ERTCRSSGSKSRGRGRK-NNPSPPPDSD-------- Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac ------------------------DRLRRGSDGKSRGRGRRNNNPSPPPDSD-------- Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac ------------------------DRPHRASDGKLRGRSKRSSDPSPAGDNE-------- 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ----------------------------------------------------LERIFIWD Praesagittifera-naikaiensis_g3512.t1_NONE ---------------DH----------------------------------NFERIFIWD Praesagittifera-naikaiensis_g3510.t1_NONE SGAGHGASFAAAGVTDYLSAYHHYYSAAYG------------------------------ Praesagittifera-naikaiensis_g17034.t1_NONE SGAGHGASFAAAGVTDYLSAYHHYYSAAYGGLGLANVIPKPNNPVPFQFSPNIPRIFIWD Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE ----------------------------------------------------LERVFVWD Drosophila-melanogaster_FBtr0079335_eyes-absent VK-------------------------------------------------PPERVFVWD Saccoglossus-kowalevskii_Sakowv30018491_NONE ----------------------------------------------------LERVFVWD Ptychodera-flava_PF33570-t1_NONE ----------------------------------------------------LERVFVWD Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ----------------------------------------------------LERVFVWD Acanthaster-planci_oki48-14_NONE ----------------------------------------------------LERVFVWD Branchiostoma-floridae_BRAFL83679_NONE ----------------------------------------------------LERVFVWD Branchiostoma-belcheri_BRBE223870R-t1_NONE ----------------------------------------------------LERVFVWD Oikopleura-dioica_GSOIDT00002684001_NONE ----------------------------------------------------IERVFIWD Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ----------------------------------------------------LERVFVWD Ciona-savignyi_ENSCSAVT00000006529.1_NONE ----------------------------------------------------LERVFVWD Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- ----------------------------------------------------LERVFLWD Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- ----------------------------------------------------LERVFIWD Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- ----------------------------------------------------LERVFVWD Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a ----------------------------------------------------IERVFVWD Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ----------------------------------------------------LERVFLWD Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac ----------------------------------------------------LERVFVWD Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac ----------------------------------------------------LERVFIWD Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac ----------------------------------------------------IERVFVWD 610 620 630 640 650 660 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein LDETIIIFHSLLTGLFATKFGK------------------------------DSPSSVAL Praesagittifera-naikaiensis_g3512.t1_NONE LDETLIIFHSLLTATFAQRFGK------------------------------DSSRGVQL Praesagittifera-naikaiensis_g3510.t1_NONE -------------AT--------------------------------------------- Praesagittifera-naikaiensis_g17034.t1_NONE LDETLIIFHSLLTATFAQRFGK------------------------------DSSRGVQL Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE LDETIIIFHSLLTGTYAQRYQK------------------------------EPQSSVQL Drosophila-melanogaster_FBtr0079335_eyes-absent LDETLIIFHTLLSGSYANRYTK------------------------------DHSSLMTI Saccoglossus-kowalevskii_Sakowv30018491_NONE LDETIIIFHSLLTGSYATRFGK------------------------------DPPSSVSL Ptychodera-flava_PF33570-t1_NONE LDETIIIFHSLLTGSYATRFGK------------------------------DPPSSVSL Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte LDETIIIFHSLLTGSYATRFGK------------------------------DAPAAVSL Acanthaster-planci_oki48-14_NONE LDETIIVFHSLLTGSYATRFGK------------------------------DAPASVSL Branchiostoma-floridae_BRAFL83679_NONE LDETIIVFHSLLTGSYAQRFGK------------------------------DPQQAVAL Branchiostoma-belcheri_BRBE223870R-t1_NONE LDETIIVFHSLLTGSYAQRFGKDPQQAVALGLRMEEMIFNLADNHLFFNDLEDPQQAVAL Oikopleura-dioica_GSOIDT00002684001_NONE LDETIIIFHSLLTSSYAQRYGK------------------------------DTNATLQL Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE LDETIIIFHSLLTSSFAQRYGK------------------------------DASSTCAL Ciona-savignyi_ENSCSAVT00000006529.1_NONE LDETIIIFHSLLTSSFAQRYGK------------------------------DASSTCAL Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- LDETIIIFHSLLTGSYAQKYGK------------------------------DPTLVIGS Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- LDETIIIFHSLLTGSYANRYGR------------------------------DPPTSVSL Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- LDETIIVFHSLLTGSYAQKYGK------------------------------DPPMAVTL Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a LDETIIIFHSLLTGTFASRYGK------------------------------DTTTSVRI Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac LDETIIIFHSLLTGSYAQKYGK------------------------------DPTVVIGS Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac LDETIIVFHSLLTGSYAQKYGK------------------------------DPPMAVTL Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac LDETIIVFHSLLTGSYANRYGR------------------------------DPPTSVSL Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac LDETIIIFHSLLTGTFASRYGK------------------------------DTTTSVRI 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein GLRMEEMIFNLADTHMFFNDLEDCDQVHIDDVAADDNGLDLSTYNFEADGFHAAATSA-- Praesagittifera-naikaiensis_g3512.t1_NONE GLAMENLIFSMADLSFFFNDLEDCDQIHVDDVVSDDNGIDLSNYNFSADG---------- Praesagittifera-naikaiensis_g3510.t1_NONE -----------------------C------------------------------------ Praesagittifera-naikaiensis_g17034.t1_NONE GLAMENLIFSMADLSFFFNDLEDCDQIHVDDVVSDDNGIDLSNYNFSADGFVSAVGSASA Lottia-gigantea_LotgiT124788_NONE ----------------------ECDQVHIDDVSSDDNGQDLSNYNFATDGFHAAANNA-- Pinctada-fucata_pfu409-130730t1_NONE GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLGTYNFAADGF---ATTT-- Drosophila-melanogaster_FBtr0079335_eyes-absent AFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAP Saccoglossus-kowalevskii_Sakowv30018491_NONE GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVASDDNGQDLSTYNFATDGFHAAATSA-- Ptychodera-flava_PF33570-t1_NONE GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVASDDNGQDLSTYNFATDGFHAAATSA-- Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte GLRMEEMIFNLADMHLFFNDLEECDQVHIDDVASDDNGQDLSNYNFQTDGFHAAATSA-- Acanthaster-planci_oki48-14_NONE GLRMEEMIFNLADTHLFFNDLE-------------------------------------- Branchiostoma-floridae_BRAFL83679_NONE GLRMEEMIFNLADNHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFATDGFHAAATSA-- Branchiostoma-belcheri_BRBE223870R-t1_NONE GLRMEEMIFNLADNHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFATDGFHAAATSA-- Oikopleura-dioica_GSOIDT00002684001_NONE GLRMEELIFNLADNHLFFNDLEECDQVHCDDVAADDNGQDLANYNFQTDGFRTANAAG-- Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE GLRMEELIFNLADNHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFATDGFR--STSG-- Ciona-savignyi_ENSCSAVT00000006529.1_NONE GLRMEELIFNLADNHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFATDGFR--STSG-- Gallus-gallus_ENSGALT00000070785.1_NONE -----------------------------------------STYNFSADGFHSSAASA-- Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- GLSMEEMIFEVADTHLFFNDLEECDQVHIEDVASDDNGQDLSNYNFSTDGFSGSGSNA-- Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSA-- Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSA-- Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a GLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASA-- Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac GLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSG-- Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSA-- Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac GLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSA-- Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac GLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGA-- 730 740 750 760 770 780 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein -NLCMA------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g3510.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g17034.t1_NONE AAAAAALSLPSTS----------------------------------------------- Lottia-gigantea_LotgiT124788_NONE -TLCLA------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE -NPNIL------------------------------------------------------ Drosophila-melanogaster_FBtr0079335_eyes-absent PNLCLP------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30018491_NONE -NLCLA------------------------------------------------------ Ptychodera-flava_PF33570-t1_NONE -NLCLA------------------------------------------------------ Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte -NLCLA------------------------------------------------------ Acanthaster-planci_oki48-14_NONE ------------------------------------------------------------ Branchiostoma-floridae_BRAFL83679_NONE -NLCLA------------------------------------------------------ Branchiostoma-belcheri_BRBE223870R-t1_NONE -NLCLATGVRGGVDWMRKLAFRYRRIKEIYNSYKNNVGGMLGPAKREQWLQLRSEIEALT Oikopleura-dioica_GSOIDT00002684001_NONE -AICLG------------------------------------------------------ Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE -NVCMA------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE -NVCMA------------------------------------------------------ Gallus-gallus_ENSGALT00000070785.1_NONE -NLCLG------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- -NHSSS------------------------------------------------------ Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- -NLCLA------------------------------------------------------ Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- -NLCLP------------------------------------------------------ Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a -NLCLG------------------------------------------------------ Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac -SHGSS------------------------------------------------------ Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac -NLCLP------------------------------------------------------ Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac -NLCLA------------------------------------------------------ Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac -NLCLG------------------------------------------------------ 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein ------------------------------------------------------------ Praesagittifera-naikaiensis_g3512.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g3510.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g17034.t1_NONE ------------------------------------------------------------ Lottia-gigantea_LotgiT124788_NONE ------------------------------------------------------------ Pinctada-fucata_pfu409-130730t1_NONE ------------------------------------------------------------ Drosophila-melanogaster_FBtr0079335_eyes-absent ------------------------------------------------------------ Saccoglossus-kowalevskii_Sakowv30018491_NONE ------------------------------------------------------------ Ptychodera-flava_PF33570-t1_NONE ------------------------------------------------------------ Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte ------------------------------------------------------------ Acanthaster-planci_oki48-14_NONE ------------------------------------------------------------ Branchiostoma-floridae_BRAFL83679_NONE ------------------------------------------------------------ Branchiostoma-belcheri_BRBE223870R-t1_NONE DSWLTIALKSLSIIHSRPEVHRPPDSRQERLGCVNPHVSPLGSENECDQVHIDDVSSDDN Oikopleura-dioica_GSOIDT00002684001_NONE ------------------------------------------------------------ Botryllus-schlosseri_botctg027751g5478_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Ciona-savignyi_ENSCSAVT00000006529.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000070785.1_NONE ------------------------------------------------------------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- ------------------------------------------------------------ Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- ------------------------------------------------------------ Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- ------------------------------------------------------------ Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a ------------------------------------------------------------ Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac ------------------------------------------------------------ Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac ------------------------------------------------------------ Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac ------------------------------------------------------------ Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac ------------------------------------------------------------ 850 860 870 880 890 900 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein --------------------------TGVRGGVDWMRKLAYRYRKIKEVYSSYRN-NVGG Praesagittifera-naikaiensis_g3512.t1_NONE --------------------------------------------KIKENYNAFRGPNISS Praesagittifera-naikaiensis_g3510.t1_NONE --------------------------------------------------------NIGT Praesagittifera-naikaiensis_g17034.t1_NONE --------------------------NAVRGGVDYLRKLSYRYRKIKENYNAFRGPNISS Lottia-gigantea_LotgiT124788_NONE --------------------------TGVRGGVDWMRKLAFRYRRMKEIYNTYRN-NVGG Pinctada-fucata_pfu409-130730t1_NONE --------------------------AGMRGGVDWMRKLAFRYRRIKEIYNSYRN-NVGG Drosophila-melanogaster_FBtr0079335_eyes-absent --------------------------TGVRGGVDWMRKLAFRYRKIKDIYNSYRG-NVGT Saccoglossus-kowalevskii_Sakowv30018491_NONE --------------------------TGVRGGVDWMRKLAFRYRRIKEIYNSYKN-NVGA Ptychodera-flava_PF33570-t1_NONE --------------------------TGVRGGVDWMRKLAFRYRRIKEIYNSYKN-NVGA Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte --------------------------TGVRGGVDWMRKLAYRYRRIKEIYSSYKN-NVGG Acanthaster-planci_oki48-14_NONE ------------------------------------------------------------ Branchiostoma-floridae_BRAFL83679_NONE --------------------------TGVRGGVDWMRKLAFRYRRIKEIYNSYKN-NVGG Branchiostoma-belcheri_BRBE223870R-t1_NONE GQDLSTYNFATDGFHAAATSANLCLATGVRGGVDWMRKLAFRYRRIKEIYNSYKN-NVGG Oikopleura-dioica_GSOIDT00002684001_NONE --------------------------PGVRGGVDWMRKLAFRYRRIKELYDTFKD-NIPE Botryllus-schlosseri_botctg027751g5478_NONE -----------------------------------MRKLAFRYRRIKEIYERYAA-NVGS Ciona-savignyi_ENSCSAVT00000006529.1_NONE --------------------------TGVRGGVDWMRKLAFRYRRIKEIYESYAG-NVQS Ciona-savignyi_ENSCSAVT00000006529.1_NONE --------------------------TGVRGGVDWMRKLAFRYRRIKEIYESYAG-NVQS Gallus-gallus_ENSGALT00000070785.1_NONE --------------------------SGVHGGVDWMRKLAFRYRRVKEMYNTYKN-NVGG Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- --------------------------VGVQGGVDWMRKLAFRYRRVREIYDKYKT-NVGG Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- --------------------------TGVRGGVDWMRKLAFRYRRVKEIYNTYKN-NVGG Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- --------------------------TGVRGGVDWMRKLAFRYRRVKELYNTYKN-NIGG Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a --------------------------SGVHGGVDWMRKLAFRYRRVKEMYNTYKN-NVGG Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac --------------------------VGVQGGVDWMRKLAFRYRKVREIYDKHKS-NVGG Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac --------------------------TGVRGGVDWMRKLAFRYRRVKELYNTYKN-NVGG Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac --------------------------TGVRGGVDWMRKLAFRYRRVKEIYNTYKN-NVGG Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac --------------------------SGVHGGVDWMRKLAFRYRRVKEMYNTYKN-NVGG 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein LLGAAKRETWLQLRMELESTTDSWLTLALKALSIIHSRTNCLNIMVTTTQLVPALAKSLL Praesagittifera-naikaiensis_g3512.t1_NONE LMGS-KREQWLQLRSEIEQYTDNWHSYAFKALNHISSRCNHVNVLVTTTQLVPAIVKTLL Praesagittifera-naikaiensis_g3510.t1_NONE LT---------------------------------------ISVKVT------------- Praesagittifera-naikaiensis_g17034.t1_NONE LMGS-KREQWLQLRSEIEQYTDNWHSYAFKALNHISSRCNHVNVLVTTTQLVPAIVKTLL Lottia-gigantea_LotgiT124788_NONE LLGTPKREQWLQLRQEIEQYTDNWLTTALRSLSIINSRTNCVNVLVTTTQLVPALAKVLL Pinctada-fucata_pfu409-130730t1_NONE LIGPEKRNHWLQLRQEIESLTDNWLTMALKSLQIINQRSNCVNVLVTTTQLVPALAKVLL Drosophila-melanogaster_FBtr0079335_eyes-absent LLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLL Saccoglossus-kowalevskii_Sakowv30018491_NONE VLGPEKRETWLQLRAEIEALTDSWLTLALKSLTLINSRSNCTNVLVTTTQLVPAVAKVLL Ptychodera-flava_PF33570-t1_NONE VLGPEKRETWLQLRAEIEALTDSWLTLALKSLTLVNSRSNCTNVLVTTTQLVPAVAKVLL Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte LLGPQKREQWLQLRAEIEAMTDSWLTIALKSLSIIHSRSNCINVLVTTTQLVPAVAKVLL Acanthaster-planci_oki48-14_NONE ------------------------------------------------------------ Branchiostoma-floridae_BRAFL83679_NONE MLGPAKREQWLQLRSEIEALTDSWLTIALKSLSIIHSRSNTVNVLVTTTQLVPALAKCLL Branchiostoma-belcheri_BRBE223870R-t1_NONE MLGPAKREQWLQLRSEIEALTDSWLTIALKSLSIIHSRSNTVNVLVTTTQLVPALAKCLL Oikopleura-dioica_GSOIDT00002684001_NONE LLSSPVGEAWRQLRTEIDQNTDNWCALALKALGLIHNRPGCVNIMVTTTQLVPAIAKCML Botryllus-schlosseri_botctg027751g5478_NONE LLAPRDRDSWLQIRQDLETVTDTWLTLAMKSLNIINQRPHCVNVLATTTQLVPALAKLML Ciona-savignyi_ENSCSAVT00000006529.1_NONE LLPSHGREPWIQLRSDLEAVTDSWLSLALKSLNIINQRPNCVNVLATTTQLVPALAKLFL Ciona-savignyi_ENSCSAVT00000006529.1_NONE LLPSHGREPWIQLRSDLEAVTDSWLSLALKSLNIINQRPNCVNVLATTTQLVPALAKLFL Gallus-gallus_ENSGALT00000070785.1_NONE LIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLL Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- LLSPQKREALQRLRTDIEVLTDSWLETALKSLLLIQSRKNCVNILITTTQLVPALAKVLL Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- LLGPAKREAWLQLRAEIEALTDSWLTLALKALTLIHSRTNCVNILVTTTQLIPALAKVLL Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- LLGPAKRDAWLQLRAEIEALTDSWLTNALKSLSIISTRSNCVNVLVTTTQLIPALAKVLL Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a LIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLL Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac LLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLL Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac LLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLL Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac LLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLL Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac LIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLL 970 980 990 1000 1010 1020 =========+=========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein YGLGALFPIENIYSATKIGKEACFERILNRFGKKCTYIVVGDGRDEETASRQMNFPFWRV Praesagittifera-naikaiensis_g3512.t1_NONE YGMSGVLDVENIYSASKIGKEECFERIIQRFGRKCSYVCVGDGKDEEQAAKMLDMPFWRI Praesagittifera-naikaiensis_g3510.t1_NONE ------------------------------------------------------------ Praesagittifera-naikaiensis_g17034.t1_NONE YG--------NEWSSGR------------------------------------------- Lottia-gigantea_LotgiT124788_NONE YGLGGVFDIDNIYSATKIGKESSFERIVSRYGRKCTYVVVGDGRDEETAAKQVNIINISL Pinctada-fucata_pfu409-130730t1_NONE YGLGGVFSIENIYSATKIGKDSCFDRIVARFGRKCTYVVVGDGRDEEQASKQMNWPFWRV Drosophila-melanogaster_FBtr0079335_eyes-absent FGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRI Saccoglossus-kowalevskii_Sakowv30018491_NONE YGLGGAFPIENIYSATKIGKESCFERIVSRFGRKVTYVAIGDGRDEEQAAKSLDIPFWRV Ptychodera-flava_PF33570-t1_NONE YGLGGVFPIENIYSATKIGKESCFERIVSRFGRKVTYVGVGDGRDEEQAAKNLDIPFWRV Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte YGLGGVFNIENVYSATRVGKESCFERIVARFGRKVTYVAIGDAKDEETAAKQLDFPFWRV Acanthaster-planci_oki48-14_NONE ------------------------------------------------------------ Branchiostoma-floridae_BRAFL83679_NONE YGLGGVFPVENIYSATKVGKESCFERIVSRFGRKVTYVVVGDGRDEEQAAKQLQWPFWRI Branchiostoma-belcheri_BRBE223870R-t1_NONE YGLGGVFPVENIYSATKVGKESCFERIVSRFGRKVTYVVVGDGRDEEQAAKQLQWPFWRI Oikopleura-dioica_GSOIDT00002684001_NONE YELGPVFNIDNVYSATKIGKESCFERIIQRFGKNVTYVCVGDGREEEIAAKTHNVPFWPI Botryllus-schlosseri_botctg027751g5478_NONE YGLGGVFNIENIYSATKIGKESCFERIIQRFGSNVTYVAVGDGRDEENAAKVAHKYNTRA Ciona-savignyi_ENSCSAVT00000006529.1_NONE YGLGEAFNIENVYSATKIGKESCFERIIQRFGRNVTYVAIGDGRDEEQAAKVHNMPFWRI Ciona-savignyi_ENSCSAVT00000006529.1_NONE YGLGEAFNIENVYSATKIGKESCFERIIQRFGRNVTYVAIGDGRDEEQAAKVHNMPFWRI Gallus-gallus_ENSGALT00000070785.1_NONE YGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKVQ------ Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- YGLGEVFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEVAAKQHNMPFWRI Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- YGLGVVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRI Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- YSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHNMPFWRI Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a YGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPIWRI Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac YGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRI Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac YSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHNMPFWRI Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac YGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRI Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac YGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRI 1030 1040 1050 1060 1070 =========+=========+=========+=========+=========+ Nematostella-vectensis_EDO37382_Predicted-protein NTH------------------SDL-----INLHHALDLGHL--------- Praesagittifera-naikaiensis_g3512.t1_NONE STH------------------ADF-----IAMLQALELDYI--------- Praesagittifera-naikaiensis_g3510.t1_NONE -------------------------------------------------- Praesagittifera-naikaiensis_g17034.t1_NONE -------------------------------------------------- Lottia-gigantea_LotgiT124788_NONE GLF------------------RNL-----YITYYTYHQ------------ Pinctada-fucata_pfu409-130730t1_NONE TNH------------------SDL-----AALHHALELSYL--------- Drosophila-melanogaster_FBtr0079335_eyes-absent SAH------------------SDI-----RALYTALDMGFL--------- Saccoglossus-kowalevskii_Sakowv30018491_NONE SSH------------------SDL-----AALHHALDLTYL--------- Ptychodera-flava_PF33570-t1_NONE SGH------------------SDL-----AALHHALDLSYL--------- Strongylocentrotus-purpuratus_SPU013869-tr_SP-EYA-Uncharacte TSH------------------SDL-----AALHHALDLGYL--------- Acanthaster-planci_oki48-14_NONE -------------------------------------------------- Branchiostoma-floridae_BRAFL83679_NONE SSH------------------NDL-----AALHHALDLNLL--------- Branchiostoma-belcheri_BRBE223870R-t1_NONE SSH------------------NDL-----AALHHALDLNLLX-------- Oikopleura-dioica_GSOIDT00002684001_NONE STH------------------NDL-----MALHQALELEYL--------- Botryllus-schlosseri_botctg027751g5478_NONE STSSKYRMIDRKDHRSIKYAGSDLWNSIPPAIRQSTSLSTLSRNTSNYRX Ciona-savignyi_ENSCSAVT00000006529.1_NONE SSH------------------SDL-----MALHHALEQDYL--------- Ciona-savignyi_ENSCSAVT00000006529.1_NONE SSH------------------SDL-----MALHHALEQDYL--------- Gallus-gallus_ENSGALT00000070785.1_NONE SVG------------------TIL-----DSSKLTFQWPFLLLGI----- Gallus-gallus_ENSGALT00000001127.5_EYA3-EYA-transcriptional- TNH------------------ADL-----VSLHQALELDFL--------- Gallus-gallus_ENSGALT00000049593.1_EYA1-EYA-transcriptional- SSH------------------SDL-----MALHHALELEYL--------- Gallus-gallus_ENSGALT00000048760.1_EYA4-EYA-transcriptional- SSH------------------SDL-----LALHQALELEYL--------- Gallus-gallus_ENSGALT00000050872.1_EYA2-Gallus-gallus-eyes-a S-----------------------------SLRHALELEYLVGASPTS-- Homo-sapiens_ENST00000373871.7_EYA3-EYA-transcriptional-coac TNH------------------GDL-----VSLHQALELDFL--------- Homo-sapiens_ENST00000531901.5_EYA4-EYA-transcriptional-coac SSH------------------SDL-----LALHQALELEYL--------- Homo-sapiens_ENST00000388742.8_EYA1-EYA-transcriptional-coac SSH------------------SDL-----MALHHALELEYL--------- Homo-sapiens_ENST00000327619.9_EYA2-EYA-transcriptional-coac SCH------------------ADL-----EALRHALELEYL---------